305371-33-9

Basic information

• Product Name: 4-(3-chloro-4-fluorophenylamino)-6-fluoro-1,7-naphthyridine-3-carbonitrile
• Synonyms: 4-(3-chloro-4-fluorophenylamino)-6-fluoro-1,7-naphthyridine-3-carbonitrile
• CAS NO: 305371-33-9
• Molecular Formula: C₁₅H₇ClF₂N₄
• Molecular Weight: 316.69
• Mol File: 305371-33-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(3-chloro-4-fluorophenylamino)-6-fluoro-1,7-naphthyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-chloro-4-fluorophenylamino)-6-fluoro-1,7-naphthyridine-3-carbonitrile(305371-33-9)
• EPA Substance Registry System: 4-(3-chloro-4-fluorophenylamino)-6-fluoro-1,7-naphthyridine-3-carbonitrile(305371-33-9)

Safety Data

• Hazardous Substances Data: 305371-33-9(Hazardous Substances Data)

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 
• 305371-18-0 4-chloro-6-fluoro-[1,7]naphthyridine-3-carbonitrile 
• 456-24-6 2-Fluoro-5-nitropyridine 
• 4548-45-2 2-chloro-5-nitropyridine 
• 1827-27-6 2-fluoro-5-aminopyridine 
• 171178-42-0 5-[N-(tert-Butoxycarbonyl)-amino]-2-fluoropyridine-4-carboxylic acid 
• 305371-15-7 5-tert-butoxycarbonylamino-2-fluoro-isonicotinic acid, methyl ester 

Downstream Products

• 871307-18-5 Tpl₂ Kinase Inhibitor 
• 915010-12-7 4-((3-chloro-4-fluorophenyl)(methyl)amino)-6-fluoro-1,7-naphthyridine-3-carbonitrile 

Relevant articles and documents

Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles

We have previously reported the discovery and initial SAR of the [1,7]naphthyridine-3-carbonitriles and quinoline-3-carbonitriles as Tumor Progression Loci-2 (Tpl2) kinase inhibitors. In this paper, we report new SAR efforts which have led to the identifi

Inhibition of Tpl2 kinase and TNF-α production with 1,7-naphthyridine-3-carbonitriles: Synthesis and structure-activity relationships

The synthesis and structure-activity studies of a series of 6-substituted-4-anilino-[1,7]-naphthyridine-3-carbonitriles as inhibitors of Tpl2 kinase are described. The early exploratory work described here may lead to the discovery of compounds with signi

Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles

The syntheses and EGFR kinase inhibitory activity of a series of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles are described. Both reversible and irreversible binding inhibitors were prepared. These series were compared with each other and with the corresponding 4-anilinoquinoline-3-carbonitriles. Compounds having a 1,7-naphthyridine core structure can retain high potency while those with a 1,8-naphthyridine core are significantly less active. These results are consistent with molecular modeling observations.