30568-27-5

Basic information

• Product Name: 2-methyl-2-(3-methylphenyl)propanenitrile
• CAS NO: 30568-27-5
• Molecular Formula: C₁₁H₁₃N
• Molecular Weight: 159.2276
• Mol File: 30568-27-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 251.5°C at 760 mmHg
• Flash Point: 109.7°C
• Density: 0.96g/cm³
• Vapor Pressure: 0.0204mmHg at 25°C
• Refractive Index: 1.507
• CAS DataBase Reference: 2-methyl-2-(3-methylphenyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2-(3-methylphenyl)propanenitrile(30568-27-5)
• EPA Substance Registry System: 2-methyl-2-(3-methylphenyl)propanenitrile(30568-27-5)

Safety Data

• Hazardous Substances Data: 30568-27-5(Hazardous Substances Data)

Usage

General Description

2-methyl-2-(3-methylphenyl)propanenitrile is a chemical compound composed of a nitrile group (‐C≡N) attached to a carbon chain with two methyl groups and a 3-methylphenyl group. It is a colorless to pale yellow liquid with a faint, aromatic odor, and it is sparingly soluble in water but soluble in most organic solvents. 2-methyl-2-(3-methylphenyl)propanenitrile is commonly used as a reagent in organic synthesis and as an intermediate in the production of various chemical compounds, including pharmaceuticals, pesticides, and dyes. It is also a potential irritant to the skin, eyes, and respiratory system, so proper handling and safety precautions are necessary when working with this substance.

Upstream product

• 2947-60-6 3-methylbenzyl cyanide 
• 74-88-4 methyl iodide 
• 78-82-0 Isobutyronitrile 
• 352-70-5 m-Fluorotoluene 

Downstream Products

• 93351-25-8 2-methyl-2-m-tolylpropanoic acid 
• 32454-27-6 2-methyl-2-(m-tolyl)propan-1-ol 
• 19884-68-5 2,3-Dimethyl-3-(3-methyl-phenyl)-2-chlor-butan 
• 363186-16-7 α,α,3-trimethylbenzeneacetic acid ethyl ester 

Relevant articles and documents

Palladium-Catalyzed Distal m-C-H Functionalization of Arylacetic Acid Derivatives

Herein, we present m-C-H olefination on derivatives of phenylacetic acids by tethering with a simple nitrile-based template through palladium catalysis. Notably, the versatility of the method is evaluated with a wide range of phenylacetic acid derivatives for obtaining the meta-olefination products in fair to excellent yields with outstanding selectivities under mild conditions. Significantly, the present strategy is successfully exemplified for the synthesis of drugs/natural product analogues (naproxen, ibuprofen, paracetamol, and cholesterol).

PPARG MODULATORS FOR TREATMENT OF OSTEOPOROSIS

The invention provides methods of treatment of a progressive bone disease, such as osteoporosis, Paget's Disease, multiple myeloma, or hyperparathyroidism, comprising administration of an effective amount of a non-agonist PPARG modulator to a patient afflicted with the disease.

Process for preparing benzylnitriles

A process is described for preparing an aromatic compound substituted by a tertiary nitrile of Formula (1.0.0): comprising treating a substituted aromatic compound of Formula (2.0.0): with a secondary nitrile of Formula (3.0.0): in the presence of a base having a pKanumerical value in the range of from about 17 to about 30, provided that the difference in pKanumerical values between said base and the corresponding tertiary nitrile of Formula (3.0.0) is no more than about 6; in an aprotic solvent having a dielectric constant (∈) of less than about 20; and at a reaction temperature in the range of from about 0° C. to about 120° C.; whereby there is formed said tertiary-nitrile-substituted aromatic compound final product of Formula (1.0.0); wherein the constituent parts W1, W2, W3, W4, and W5; and the substituent moieties R1, R2, R3, R4, R5, R6, and R7in the compounds of Formulas (1.0.0), (2.0.0) and (3.0.0) are selected from known organic groups and radicals as further detailed in the instant specification.