306272-46-8

Basic information

• Product Name: C₁₂H₁₄N₂O₆
• Synonyms: C₁₂H₁₄N₂O₆
• CAS NO: 306272-46-8
• Molecular Weight: 282.253
• Mol File: 306272-46-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₄N₂O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₄N₂O₆(306272-46-8)
• EPA Substance Registry System: C₁₂H₁₄N₂O₆(306272-46-8)

Safety Data

• Hazardous Substances Data: 306272-46-8(Hazardous Substances Data)

Upstream product

• 1135-24-6 3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 4665-58-1 2-nitroxyethylammonium nitrate 

Relevant articles and documents

Synthesis and evaluation of nitric oxide-releasing derivatives of 3-n-butylphthalide as anti-platelet agents

Most ischemic stroke results from brain blood vessel blockage by platelet-mediated thrombus, and anti-platelet therapy has been demonstrated clinical benefits in the treatment of this disease. In the present work, novel nitric oxide (NO)-releasing derivatives of an anti-ischemic stroke drug 3-n-butylphthalide (NBP) were synthesized. Compounds 7a and 7c exhibited more potent anti-platelet activity than NBP and aspirin, and released a moderate amount of NO, which is beneficial in improving cardiovascular and cerebral circulation. These findings provide an alternative approach to the development of drugs more potent than NBP for the intervention of ischemic stroke.