3065-27-8

Basic information

• Product Name: 2,4,5-trichlorophenyl 3-phenyl-N-[(phenylmethoxy)carbonyl]-L-alaninate
• Synonyms: 2,4,5-trichlorophenyl 3-phenyl-N-[(phenylmethoxy)carbonyl]-L-alaninate;N-[(Benzyloxy)carbonyl]-L-phenylalanine 2,4,5-trichlorophenyl ester
• CAS NO: 3065-27-8
• Molecular Formula: C₂₃H₁₈Cl₃NO₄
• Molecular Weight: 478.75232
• EINECS: 221-314-6
• Mol File: 3065-27-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 633.5°Cat760mmHg
• Flash Point: 336.9°C
• Appearance: /
• Density: 1.381g/cm³
• Vapor Pressure: 5.91E-16mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 2,4,5-trichlorophenyl 3-phenyl-N-[(phenylmethoxy)carbonyl]-L-alaninate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-trichlorophenyl 3-phenyl-N-[(phenylmethoxy)carbonyl]-L-alaninate(3065-27-8)
• EPA Substance Registry System: 2,4,5-trichlorophenyl 3-phenyl-N-[(phenylmethoxy)carbonyl]-L-alaninate(3065-27-8)

Safety Data

• Hazardous Substances Data: 3065-27-8(Hazardous Substances Data)

Usage

General Description

2,4,5-trichlorophenyl 3-phenyl-N-[(phenylmethoxy)carbonyl]-L-alaninate is a chemical compound that belongs to the class of carboxylic acid esters. It is a derivative of L-alanine and contains a phenyl group and a 2,4,5-trichlorophenyl group. 2,4,5-trichlorophenyl 3-phenyl-N-[(phenylmethoxy)carbonyl]-L-alaninate is commonly used as a pesticide or herbicide due to its ability to inhibit the growth of unwanted plants or pests. It works by interfering with vital metabolic processes in the target organisms, ultimately leading to their death. Additionally, it can also be used as an intermediate in the synthesis of other chemical compounds. Despite its potential applications, this chemical should be handled with care and in accordance with safety guidelines to minimize any potential risks to human health and the environment.

InChI:InChI=1/C23H18Cl3NO4/c24-17-12-19(26)21(13-18(17)25)31-22(28)20(11-15-7-3-1-4-8-15)27-23(29)30-14-16-9-5-2-6-10-16/h1-10,12-13,20H,11,14H2,(H,27,29)

Upstream product

• 1161-13-3 N-Cbz-L-Phe 
• 95-95-4 2,4,5-trichlorophenol 
• 16947-69-6 2,4,5-Trichlorophenyl chloroformate 
• 13795-27-2 (2,4,5-Trichlorphenyl)-benzyl-carbonat 
• 16480-57-2 L-phenylalanine sodium salt 

Downstream Products

• 69193-13-1 Cbz-L-Phe-L-Leu-NH₂ 
• 71450-10-7 benzyl N-((1S)-2-[(1S)-1-(aminocarbonyl)-3-(methylsulfanyl)propyl]amino-1-benzyl-2-oxoethyl)carbamate 
• 91291-34-8 Z-Phe-Val-Sta-Ala-Sta-OCH₃ 
• 92628-14-3 Z-Phe-Ile-Sta-Ala-Sta-OCH₃ 
• 92608-46-3 Z-Phe-Pro-Sta-Ala-Sta-OCH₃ 
• 91291-37-1 Z-Phe-D-Phe-Sta-Ala-Sta-OCH₃ 
• 91291-37-1 Z-Phe-Phe-Sta-Ala-Sta-OCH₃ 
• 91291-43-9 Z-Phe-Trp-Sta-Ala-Sta-OCH₃ 
• 16947-10-7 N--funtumin 
• 16947-14-1 3β-<(Benzyloxycarbonyl-Phe-Gly)-amino>-5β-pregnanon-(20) 

Relevant articles and documents

A remarkable catalytic effect of the potassium salt of 1-hydroxybenzotriazole on peptide bond formation

A semiquantitative investigation was done on the catalytic effects of 1-hydroxybenzotriazole (HOBt) (5) and the potassium salt 6 of HOBt (5) on peptide bond formation by the active ester method. HOBt (5) was found to catalyze the aminolysis reaction of two different types of active esters, benzyloxy-carbonyl-l-phenylalanine 2,4,5-trichlorophenyl ester (1) and benzyloxycarbonyl-l-phenylalanine 1-succinimidyl ester (2), in tetrahydrofuran (THF) and in a dipolar aprotic dimethylformamide (DMF) solvent. A large rate enhancement was also observed in the aminolysis reaction of 1 in THF when the potassium salt 6 of HOBt (5) was added in the presence of dicyclohexyl-18-crown-6 (7). The rate acceleration in the aminolysis reaction of the active esters by 5 and 6 may reasonably be explained in terms of nucleophilic catalysis.

The trifluoroacetate method of peptide synthesis. I. The synthesis and use of trifluoroacetate reagents.

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