30675-13-9

Basic information

• Product Name: TCID
• Synonyms: 4,5,6,7-TETRACHLOROINDAN-1,3-DIONE;4,5,6,7-TETRACHLOROINDANE-1,3-DIONE;4,5,6,7-TETRACHLORO-1H-INDENE-1,3(2H)-DIONE;4,5,6,7-Tetrachloro-1,3-indanedione;4,5,6,7-Tetrachloroindane-1,3-dione 95+%;4,5,6,7-tetrachloro-2,3-dihydro-1H-indene-1,3-dione;TCID;1H-Indene-1,3(2H)-dione, 4,5,6,7-tetrachloro-
• CAS NO: 30675-13-9
• Molecular Formula: C₉H₂Cl₄O₂
• Molecular Weight: 283.92
• EINECS: 210-109-7
• Product Categories: Inhibitors
• Mol File: 30675-13-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 218-220
• Boiling Point: 448.1°C at 760 mmHg
• Flash Point: 188.8°C
• Appearance: /
• Density: 1.782g/cm³
• Vapor Pressure: 3.18E-08mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: +2C to +8C
• Solubility: Soluble in DMSO (up to 25 mg/ml),
• PKA: 8.62±0.20(Predicted)
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
• CAS DataBase Reference: TCID(CAS DataBase Reference)
• NIST Chemistry Reference: TCID(30675-13-9)
• EPA Substance Registry System: TCID(30675-13-9)

Safety Data

• Hazard Codes: Xi
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 30675-13-9(Hazardous Substances Data)

Usage

Description

TCID (30675-13-9) is a small molecule inhibitor of DNA polymerase λ, which also inhibits ubiquitin C-terminal hydrolase L3 (UCH-L3) with an IC50 of 0.6 μM. It is 125-fold selective over UCH-L1, with an IC50 of 75 μM, and is cell permeable.

Uses

Used in Pharmaceutical Industry:
TCID is used as a pharmaceutical agent for inhibiting DNA polymerase λ and UCH-L3. Its high selectivity and cell permeability make it a promising candidate for the development of new therapeutic strategies targeting these enzymes.
Used in Research Applications:
TCID is used as a research tool for studying the roles of DNA polymerase λ and UCH-L3 in various cellular processes. Its ability to selectively inhibit these enzymes allows researchers to investigate their functions and potential involvement in disease pathways.
Used in Drug Development:
TCID is used as a lead compound in the development of new drugs targeting DNA polymerase λ and UCH-L3. Its potent inhibition and selectivity make it a valuable starting point for designing more effective and specific inhibitors for therapeutic use.

References

1) Love et al. (2007), Mechanisms, biology and inhibitors of deubiquitinating enzymes; Nat. Chem. Biol., 3 697 2) Mtango et al. (2012), Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation; J. Cell Physiol., 227 2022

InChI:InChI=1/C9H2Cl4O2/c10-6-4-2(14)1-3(15)5(4)7(11)9(13)8(6)12/h1H2

Upstream product

• 117-08-8 tetrachlorophthalic anhydride 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 60423-62-3 2-Benzhydryl-4,5,6,7-tetrachlor-1,3-indandion 

Relevant articles and documents

Cyclopropanation of active methylene compounds with β-alkoxycarbonyl vinylsulfonium salts

An efficient synthesis of β-alkoxycarbonyl vinylsulfonium salts had been developed. Their reaction with indene-1,3-diones and other active methylene compounds provided cyclopropane carboxylates in good yields. A tentative reaction mechanism was proposed.

Studies on substances having antiviral activity. Thiosemicarbazones of indandione, cyclopentenediones and pentanediones

In order to evaluate the effect of structural modifications on antiviral activity of the dithiosemicarbazones of 1,3 indandione and 2 hydroxyimino 1,3 indandione, several derivatives of substituted 1,3 indandiones, 4 cyclopenten 1,3 diones and 2,4 pentand