307313-04-8

Basic information

• Product Name: Pyrazolo[1,5-a]pyridine-2-carbonyl chloride, 4,5,6,7-tetrahydro- (9CI)
• Synonyms: Pyrazolo[1,5-a]pyridine-2-carbonyl chloride, 4,5,6,7-tetrahydro- (9CI);4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-2-carboxylic acid chloride
• CAS NO: 307313-04-8
• Molecular Formula: C8H9ClN2O
• Molecular Weight: 184.62286
• Product Categories: ACIDHALIDE
• Mol File: 307313-04-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrazolo[1,5-a]pyridine-2-carbonyl chloride, 4,5,6,7-tetrahydro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazolo[1,5-a]pyridine-2-carbonyl chloride, 4,5,6,7-tetrahydro- (9CI)(307313-04-8)
• EPA Substance Registry System: Pyrazolo[1,5-a]pyridine-2-carbonyl chloride, 4,5,6,7-tetrahydro- (9CI)(307313-04-8)

Safety Data

• Hazardous Substances Data: 307313-04-8(Hazardous Substances Data)

Upstream product

• 307313-03-7 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid 
• 4043-87-2 pipecolic Acid 
• 105786-95-6 4,5,6,7-tetrahydro<1.2.3>oxadiazolo<3,4-a>pyridin-3-one 
• 307307-82-0 methyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylate 

Downstream Products

• 1448862-14-3 C₁₄H₁₆N₄O₂ 

Relevant articles and documents

A novel series of metabotropic glutamate receptor 5 negative allosteric modulators based on a 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine core

A series of potent non-acetylinic negative allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5 NAMs) was developed starting from HTS screening hit 1. Potency was improved via iterative SAR, and physicochemical properties were optimized to deliver orally bioavailable compounds acceptable for in vivo testing. A lead molecule from the series demonstrated dose-dependent activity in the second phase of the rat formalin test from 30 mg/kg, and a preliminary PK/PD relationship was established.