308243-58-5

Basic information

• Product Name: 4-[4-chloro-2-(2-fluoro-benzoyl)-phenylcarbamoyl]-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid methyl ester
• Synonyms: 4-[4-chloro-2-(2-fluoro-benzoyl)-phenylcarbamoyl]-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid methyl ester
• CAS NO: 308243-58-5
• Molecular Weight: 615.058
• Mol File: 308243-58-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-[4-chloro-2-(2-fluoro-benzoyl)-phenylcarbamoyl]-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-chloro-2-(2-fluoro-benzoyl)-phenylcarbamoyl]-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid methyl ester(308243-58-5)
• EPA Substance Registry System: 4-[4-chloro-2-(2-fluoro-benzoyl)-phenylcarbamoyl]-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid methyl ester(308243-58-5)

Safety Data

• Hazardous Substances Data: 308243-58-5(Hazardous Substances Data)

Upstream product

• 784-38-3 2-amino-5-chloro-2'-fluorobenzophenone 
• 1481642-14-1 (S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-methoxy-5-oxopentanoic acid 
• 308243-40-5 4-chlorocarbonyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid methyl ester 

Downstream Products

• 308242-30-0 3-[7-chloro-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-propionic acid butyl ester 
• 308242-14-0 (S)-3-(7-chloro-2-oxo-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propionic acid methyl ester 

Relevant articles and documents

Novel benzodiazepines derivatives as analgesic modulating for Transient receptor potential vanilloid 1

A new series of derivatives of 3-(7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanoic acid were designed and synthesized as analgesic modulating for Transient receptor potential vanilloid 1. They were investigated for TRPV1 antagonistic activity in vitro, analgesic activity and sedative activity in vivo and aqueous solubility. Preliminary studies identified 3-(7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-N,N-dimethylpropanamide(Compound 11), as a potent analgesic modulating for TRPV1 with potent activity and good aqueous solubility.

Identification and structure-activity studies of novel ultrashort-acting benzodiazepine receptor agonists

The synthesis and evaluation of novel ultrashort-acting benzodiazepine (USA BZD) agonists are described. A BZD scaffold was modified by incorporation of amino acids and derivatives. The propionate side chain of glutamic acid tethers an enzymatically labile functionality where the metabolite carboxylic acid displays markedly reduced BZD receptor affinity. The USA BZDs were characterized by full agonism profiles.