310455-62-0

Basic information

• Product Name: 3-(4-trifluoromethylbenzyl)-8-hydroxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one
• CAS NO: 310455-62-0
• Molecular Weight: 375.347
• Mol File: 310455-62-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(4-trifluoromethylbenzyl)-8-hydroxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-trifluoromethylbenzyl)-8-hydroxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one(310455-62-0)
• EPA Substance Registry System: 3-(4-trifluoromethylbenzyl)-8-hydroxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one(310455-62-0)

Safety Data

• Hazardous Substances Data: 310455-62-0(Hazardous Substances Data)

Upstream product

• 108-46-3 recorcinol 
• 71486-53-8 methyl 4-oxo-3-piperidinecarboxylate hydrochloride 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 193217-48-0 1,2,3,4-tetrahydro-8-hydroxychromeno[3,4-c]pyridin-5-one 

Relevant articles and documents

Synthesis of Two Dopamine D4 Receptor Ligands: 11C Labelled Chromeno[3,4-c]pyridin-5-ones

The synthesis of two 11C labelled chromeno[3,4-c]pyridin-5-ones for the visualisation of the dopamine D4 receptor subtype has been developed. The production entailed an (9-methylation of the O-desmethyl precursor with [11C]iodomethane in the presence of tetrabutylammonium hydroxide. Subsequent purification by RP-HPLC and formulation by tracer enrichment on a CIS Sep Pak provided a solution which was suitable for human iv injection. Specific activity of the tracer averaged 37 GBq/μmol at EOS and the radiochemical yields were 65 percent (decay-corrected, based on [11C]CH3I). Total activity obtained was 5.6 - 7.4 GBq. The preparations have been demonstrated to be chemically and radiochemically pure by HPLC.