31075-58-8

Basic information

• Product Name: 2-MORPHOLIN-4-YL-1H-BENZIMIDAZOLE
• Synonyms: 2-MORPHOLIN-4-YL-1H-BENZIMIDAZOLE;2-(4-MORPHOLINYL)-1H-BENZIMIDAZOLE;TIMTEC-BB SBB014811;2-(4-morpholinyl)-1H-benzimidazole(SALTDATA: FREE);2-Morpholin-4-yl-1H-benzoimidazole;2-morpholino-1H-benzimidazole
• CAS NO: 31075-58-8
• Molecular Formula: C11H13N3O
• Molecular Weight: 203.24
• Mol File: 31075-58-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 408.5°C at 760 mmHg
• Flash Point: 200.9°C
• Appearance: /
• Density: 1.283g/cm³
• Vapor Pressure: 6.95E-07mmHg at 25°C
• Refractive Index: 1.659
• PKA: 11.77±0.10(Predicted)
• CAS DataBase Reference: 2-MORPHOLIN-4-YL-1H-BENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-MORPHOLIN-4-YL-1H-BENZIMIDAZOLE(31075-58-8)
• EPA Substance Registry System: 2-MORPHOLIN-4-YL-1H-BENZIMIDAZOLE(31075-58-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 31075-58-8(Hazardous Substances Data)

Usage

General Description

2-MORPHOLIN-4-YL-1H-BENZIMIDAZOLE is a chemical compound with potential bioactive and pharmacological properties. It is a benzimidazole derivative containing a morpholine group, which gives it unique characteristics and potential applications in medicinal chemistry. 2-MORPHOLIN-4-YL-1H-BENZIMIDAZOLE has been studied for its potential as an anti-cancer agent and for its ability to inhibit cell proliferation in certain cancer cell lines. Additionally, it has shown potential as an antiviral and antimicrobial agent, with promising activity against certain viruses and bacteria. Research on this compound is ongoing, and it holds potential for the development of novel therapeutics in the fields of oncology, virology, and microbiology.

InChI:InChI=1/C11H13N3O/c1-2-4-10-9(3-1)12-11(13-10)14-5-7-15-8-6-14/h1-4H,5-8H2,(H,12,13)

Upstream product

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Relevant articles and documents

Design, Synthesis, Cytotoxicity, and Molecular Docking Studies of New Benzimidazole Hybrids as Possible Anticancer Agents

In the course of efforts to develop new anticancer agents, benzimidazole-based morpholine, thiomorpholine, and piperazine hybrid compounds were designed and synthesized. The structures of the synthesized compounds were confirmed by Proton nuclear magnetic resonance, Carbon-13 NMR, and mass spectroscopy. The title compounds were screened for cytotoxicity against breast and lung cancer cell lines. Compound 6c was found most active against lung cancer cell line with IC50 value of 2.11 μM and compound 10c was found most active against breast cancer cell line with IC50 of 2.23 μM. The molecular docking analysis was also carried out to explore binding pattern of compound with the target protein. All synthesized compounds showed excellent binding affinity toward target protein. Therefore, these findings will be helpful in future drug design of more potent anticancer agents.

Eco-friendly strategy: design and synthesis of biologically potent benzimidazole-amine hybrids via visible-light generated oxidative C-H arylamylation of analenic amidines

An operationally simple visible light mediated intramolecular cyclization of benzimidazole to 2-amino benzimidazole hybrid. The disclosed procedure is rapid and the convenient synthesis of benzimidazole-amine hybrids from easily available substituted cycl

A DBU-diheteroaryl halide adduct as the fastest current N-diheteroarylating agent

An unexpected diazabicyclo[5.4.0]undec-7-ene (DBU) catalysed rate enhancement of N-arylation of amines with diheteroaryl halides is reported. DBU is found to activate the Ar-Cl bond of a diheteroaryl halide, forming a green coloured adduct under neat conditions. The activated green coloured adduct was used for the arylation of amines under neat conditions and was found to be the fastest diheteroarylating agent reported to date. The Royal Society of Chemistry 2013.