3111-60-2

Basic information

• Product Name: 2-[1-(4-CHLOROPHENYL)ETHYLIDENE]MALONONITRILE
• Synonyms: 2-[1-(4-CHLOROPHENYL)ETHYLIDENE]MALONONITRILE;3-(4-CHLOROPHENYL)-2-CYANOBUTYRONITRILE
• CAS NO: 3111-60-2
• Molecular Formula: C₁₁H₇ClN₂
• Molecular Weight: 202.64
• Mol File: 3111-60-2.mol
• Article Data: 16

Chemical Properties

• Melting Point: 93 °C
• Boiling Point: 325.8°Cat760mmHg
• Flash Point: 136.4°C
• Appearance: /
• Density: 1.225g/cm³
• Vapor Pressure: 0.000225mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: 2-[1-(4-CHLOROPHENYL)ETHYLIDENE]MALONONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(4-CHLOROPHENYL)ETHYLIDENE]MALONONITRILE(3111-60-2)
• EPA Substance Registry System: 2-[1-(4-CHLOROPHENYL)ETHYLIDENE]MALONONITRILE(3111-60-2)

Safety Data

• Hazardous Substances Data: 3111-60-2(Hazardous Substances Data)

Usage

General Description

2-[1-(4-CHLOROPHENYL)ETHYLIDENE]MALONONITRILE is a chemical compound with the molecular formula C13H8ClN3. It is a malononitrile derivative that contains a 4-chlorophenyl group and an ethylidene group. This chemical is commonly used as a reagent for the synthesis of various organic compounds. It is also known to exhibit biological activity, potentially acting as an inhibitor for certain enzymes. Additionally, it has been studied for its potential use in the development of pharmaceuticals and agrochemicals. However, due to its toxic and reactive nature, proper handling and safety precautions are necessary when working with this compound.

InChI:InChI=1/C11H7ClN2/c1-8(10(6-13)7-14)9-2-4-11(12)5-3-9/h2-5H,1H3

Upstream product

• 99-91-2 para-chloroacetophenone 
• 109-77-3 malononitrile 
• 115998-04-4 2-[2-Bromo-1-(4-chloro-phenyl)-ethylidene]-malononitrile 
• 108-98-5 thiophenol 
• 98-86-2 acetophenone 

Downstream Products

• 21448-26-0 3-(4-Chlorphenyl)-2.2-dicyan-buttersaeure-ethylester 
• 23250-07-9 1-Phenyl-3-(4-chlor-phenyl)-2.2-dicyan-butanon-⁽¹⁾ 
• 89507-37-9 [6-Amino-4-(4-chloro-phenyl)-5-cyano-thiopyran-(2E)-ylidene]-cyano-acetic acid ethyl ester 
• 79111-74-3 4-(4-Chlorphenyl)-2-methylthio-penta-1,4-dien-1,1,5,5-tetracarbonitril 
• 72503-65-2 (E)-5-(4-Chloro-phenyl)-2,6,6-tricyano-3-methylsulfanyl-hexa-2,5-dienoic acid ethyl ester 
• 77198-34-6 2-Amino-4-(4-chloro-phenyl)-6-phenyl-cyclohexa-2,4-diene-1,1,3-tricarbonitrile 
• 104581-09-1 5'-amino-4-chloro-4''-methyl-1,1':3',1''-terphenyl-4',6'-dicarbonitrile 
• 144738-21-6 2-{1-(4-Chloro-phenyl)-2-[(4-chloro-phenyl)-hydrazono]-ethylidene}-malononitrile 
• 80067-23-8 2-{1-(4-Chloro-phenyl)-2-[5-phenyl-[1,2]dithiol-(3Z)-ylidene]-ethylidene}-malononitrile 
• 106000-61-7 2-Amino-4,6-bis-(4-chloro-phenyl)-6-methyl-cyclohexa-2,4-diene-1,1,3-tricarbonitrile 
• 131534-29-7 2-amino-4-(p-chlorophenyl)-4-methyl-6-phenyl-4H-pyran-3,5-dicarbonitrile 
• 143644-48-8 6-amino-4-(4-chlorophenyl)-1,2-dihydro-2-oxo-1-phenylpyridine-5-carbonitrile 
• 143644-49-9 5-(4-chlorophenyl)-2,7-dithioxo-3,8-diphenyl-1,2,3,7,8-pentahydropyrido<2,3-d>pyrimidine-4-imine 
• 127844-80-8 <2-Phenylhydrazono-1-(4-chlorophenyl)ethylidene>malononitrile 

Relevant articles and documents

Exploitation of dual character of CN moiety in the synthesis of uniquely decorated 3 H-pyrroles: A rare observation

This is the first report of an innovative, one-pot, organocatalyzed, multicomponent synthesis of 3H-pyrroles from ketones, thiols, and malononitrile in ecofriendly solvent water. The approach to 3H-pyrroles presented herein offers, for the first time, an unprecedented coupling which leads to the construction of the nitrogen containing ring without starting from any amine moiety. In this context, cyanide-based multicomponent reactions involving the dual nature of the CN moiety has blossomed in an unprecedented way.

A [5 + 1] annulation strategy for the synthesis of multifunctional biaryls and: P -teraryls from 1,6-Michael acceptor ketene dithioacetals

A new type of ketene dithioacetal, 2-(3,3-bis-methylsulfanyl-1-arylallylidene)malononitriles containing 1,4 and 1,6-Michael acceptors, were synthesized to study their reactivity for the synthesis of a new molecular entity. We report a [5 + 1] annulation s

"on Water" Direct Catalytic Vinylogous Aldol Reaction of Silyl Glyoxylates

The unique reactivity of water in the direct catalytic vinylogous aldol reaction of silyl glyoxylates is reported. With the hydrogen-bonding networks from water, the unfavorable homogeneous reactions in organic solvents were severely suppressed, and the "