311346-76-6

Basic information

• Product Name: L-Alanine, N-(4-fluoro-2-nitrophenyl)-, ethyl ester
• CAS NO: 311346-76-6
• Molecular Formula: C11H13FN2O4
• Molecular Weight: 256.234
• Mol File: 311346-76-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Alanine, N-(4-fluoro-2-nitrophenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-(4-fluoro-2-nitrophenyl)-, ethyl ester(311346-76-6)
• EPA Substance Registry System: L-Alanine, N-(4-fluoro-2-nitrophenyl)-, ethyl ester(311346-76-6)

Safety Data

• Hazardous Substances Data: 311346-76-6(Hazardous Substances Data)

Upstream product

• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 1115-59-9 (S)-alanine ethyl ester hydrochloride 

Relevant articles and documents

Design and synthesis of π-extended resveratrol analogues and in vitro antioxidant and anti-inflammatory activity evaluation

The research on resveratrol (1) has been conducted intensively over a long time due to its proven antioxidant activity and disease-fighting capabilities. Many efforts have also been made to increase these biological effects. In the present study, six new extended aromatic resveratrol analogues containing naphthalene (2) and its bioisosteres quinoline (3 and 4), isoquinoline (5) quinoxaline (6) and quinazoline (7) scaffolds were designed and synthesized using an annulation strategy. The antioxidant and anti-inflammatory activities of these compounds were investigated. All compounds showed better antioxidant activity than resveratrol in ABTS assay. As for the anti-inflammatory test, 5 and 7 exhibited better activity than resveratrol. It is worth noting that nitrogen substitution on the extended aromatic resveratrol analogues has a significant impact on cell viability. Taking the antioxidant activities and NO inhibition activities into consideration, we conclude that isoquinoline analogue 5 may qualify for the further investigation of antioxidant and anti-inflammatory therapy. Furthermore, our study results suggest that in order to improve the biological activity of polyphenolic compounds, extended aromaticity and nitrogen substitution strategy could be a viable method for the design of future drug candidates.