311813-99-7

Basic information

• Product Name: 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid (3-chloro-phenyl)-amide
• CAS NO: 311813-99-7
• Molecular Weight: 280.67
• Mol File: 311813-99-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid (3-chloro-phenyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid (3-chloro-phenyl)-amide(311813-99-7)
• EPA Substance Registry System: 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid (3-chloro-phenyl)-amide(311813-99-7)

Safety Data

• Hazardous Substances Data: 311813-99-7(Hazardous Substances Data)

Upstream product

• 92534-69-5 1-methyl-4-nitro-1H-pyrazole-5-carboxylic acid 
• 16034-46-1 1-methyl-1H-pyrazole-5-carboxylic acid 
• 1006962-20-4 1-methyl-4-nitro-1H-pyrazole-5-carbonyl chloride 
• 108-42-9 3-chloro-aniline 

Downstream Products

• 957313-12-1 4-amino-2-methyl-2H-pyrazole-3-carboxylic acid (3-chloro-phenyl)-amide 

Relevant articles and documents

ortho-Substituted azoles as selective and dual inhibitors of VEGF receptors 1 and 2

We have developed a series of novel potent ortho-substituted azole derivatives active against kinases VEGFR-1 and VEGFR-2. Both specific and dual ATP-competitive inhibitors of VEGFR-2 were identified. Kinase activity and selectivity could be controlled by varying the arylamido substituents at the azole ring. The most specific molecule (17) displayed >10-fold selectivity for VEGFR-2 over VEGFR-1. Compound activities in enzymatic and cell-based assays were in the range of activities for reported clinical and development candidates (IC50 30 × 10-5 cm/min) is indicative of their potential for intestinal absorption upon oral administration.