312-24-3

Basic information

• Product Name: difluoro-phenyl-acetyl chloride
• Synonyms: difluoro-phenyl-acetyl chloride
• CAS NO: 312-24-3
• Molecular Weight: 190.577
• Mol File: 312-24-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: difluoro-phenyl-acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: difluoro-phenyl-acetyl chloride(312-24-3)
• EPA Substance Registry System: difluoro-phenyl-acetyl chloride(312-24-3)

Safety Data

• Hazardous Substances Data: 312-24-3(Hazardous Substances Data)

Upstream product

• 383-19-7 2,2-difluoro-2-phenylacetamide 
• 2002-72-4 α,α-difluorobenzeneacetonitrile 
• 40626-45-7 α,α-dichlorobenzylcyanide 
• 360-03-2 2,2-Difluoro-2-phenylacetic acid 

Downstream Products

• 1574401-91-4 ethyl 6-(difluoro(phenyl)methyl)nicotinate 
• 19450-54-5 2,2-Difluoro-N-(octahydro-naphthalen-4a-yl)-2-phenyl-acetamide 
• 339-30-0 2,2-difluoro-N-2-diphenylacetamide 
• 2248-46-6 ethyl 2,2-difluoro-2-phenylacetate 
• 1041934-93-3 C₁₀H₁₁F₂NO₂ 

Relevant articles and documents

Synthesis of N-trifluoromethyl amides from carboxylic acids

Found in biomolecules, pharmaceuticals, and agrochemicals, amide-containing molecules are ubiquitous in nature, and their derivatization represents a significant methodological goal in fluorine chemistry. Trifluoromethyl amides have emerged as important functional groups frequently found in pharmaceutical compounds. To date, there is no strategy for synthesizing N-trifluoromethyl amides from abundant organic carboxylic acid derivatives, which are ideal starting materials in amide synthesis. Here, we report the synthesis of N-trifluoromethyl amides from carboxylic acid halides and esters under mild conditions via isothiocyanates in the presence of silver fluoride at room temperature. Through this strategy, isothiocyanates are desulfurized with AgF, and then the formed derivative is acylated to afford N-trifluoromethyl amides, including previously inaccessible structures. This method shows broad scope, provides a platform for rapidly generating N-trifluoromethyl amides by virtue of the diversity and availability of both reaction partners, and should find application in the modification of advanced intermediates.

A scalable and regioselective synthesis of 2-difluoromethyl pyridines from commodity chemicals

A scalable de novo synthesis of difluoromethyl pyridines from inexpensive materials is reported. The pyridyl subunit is built around the difluoromethyl group rather than a late stage introduction of this moiety. This user-friendly approach allows access to a diverse range of substitution patterns on all positions on the ring system and on the difluoromethyl group.