312-31-2

Basic information

• Product Name: 1-fluoro-4-(phenylsulphonyl)benzene
• Synonyms: 1-fluoro-4-(phenylsulphonyl)benzene;(4-Fluorophenyl)phenyl sulfone;1-Fluoro-4-(phenylsulfonyl)benzene;p-Fluorophenylphenyl sulfone;Phenyl(4-fluorophenyl) sulfone;1-(benzenesulfonyl)-4-fluorobenzene
• CAS NO: 312-31-2
• Molecular Formula: C₁₂H₉FO₂S
• Molecular Weight: 236.2620632
• EINECS: 206-225-2
• Mol File: 312-31-2.mol
• Article Data: 38

Chemical Properties

• Melting Point: 113 °C
• Boiling Point: 373.4°Cat760mmHg
• Flash Point: 179.7°C
• Appearance: /
• Density: 1.298g/cm³
• Vapor Pressure: 1.92E-05mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: 1-fluoro-4-(phenylsulphonyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-fluoro-4-(phenylsulphonyl)benzene(312-31-2)
• EPA Substance Registry System: 1-fluoro-4-(phenylsulphonyl)benzene(312-31-2)

Safety Data

• Hazardous Substances Data: 312-31-2(Hazardous Substances Data)

Usage

Uses

1-(Benzenesulfonyl)-4-fluorobenzene is used in preparation of Diaryl Sulfone compounds.

InChI:InChI=1/C12H9FO2S/c13-10-6-8-12(9-7-10)16(14,15)11-4-2-1-3-5-11/h1-9H

Upstream product

• 330-85-8 1-fluoro-4-(phenylthio)benzene 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 14101-14-5 (4-fluorophenyl)trimethyltin 
• 98-09-9 benzenesulfonyl chloride 
• 462-06-6 fluorobenzene 
• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 98-80-6 phenylboronic acid 
• 352-34-1 4-fluoro-1-iodobenzene 
• 3111-52-2 potassium thiophenolate 
• 1765-93-1 4-fluoroboronic acid 
• 873-55-2 sodium benzenesulfonate 
• 66003-76-7 Diphenyliodonium triflate 
• 618-41-7 Benzenesulfinic acid 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 383-21-1 (4-fluoro-3-nitro-phenyl)-(3-nitro-phenyl)-sulfone 
• 47189-05-9 1-phenoxy-4-(phenylsulfonyl)benzene 
• 16237-46-0 2--propan 
• 130206-42-7 6-{[(4-Benzenesulfonyl-phenyl)-prop-2-ynyl-amino]-methyl}-2-methyl-3H-quinazolin-4-one 
• 83642-29-9 4-(4-(phenylsulfonyl)phenoxy)-1,2-dichlorobenzene 
• 1387002-71-2 2-methyl-8-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine 
• 1387002-73-4 8-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine 
• 1387002-70-1 1-methylpiperidin-4-one-O-4-(phenylsulfonyl)phenyl oxime 

Relevant articles and documents

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Metal-free sulfonylation of arenes with: N -fluorobenzenesulfonimide via cleavage of S-N bonds: expeditious synthesis of diarylsulfones

A novel metal-free sulfonylation of arenes with N-fluorobenzenesulfonimide (NFSI) toward the synthesis of diarylsulfones has been developed. The reaction represents a rare example of sulfonylation reaction using NFSI as an efficient sulfonyl donor and the first example of acid-mediated sulfonylation of unactivated arenes with NFSI via selective cleavage of S-N bonds. This protocol provides a concise approach for the construction of pharmaceutically and biologically important diarylsulfones. Applications in the functionalization of natural products (e.g., β-estradiol) and in the synthesis of a key intermediate to an inhibitor of farnesyl-protein transferase, as well as in the gram-scale synthesis of the EPAC2 antagonist, are demonstrated. This journal is

Method for synthesizing sulfone compounds under photocatalysis condition

The invention belongs to the technical field of compound preparation, and particularly relates to a method for synthesizing sulfone compounds under a photocatalysis condition. Aromatic hydrazine and sulfinate are used as raw materials, and under the action of alkali and a solvent, a sulfone compound is generated through reaction under the condition of air or oxygen under the illumination of visible light. According to the method disclosed by the invention, aryl hydrazine is used as an arylation reagent, polyacid salt is used as a catalyst or an organic photosensitizer is used as a catalyst, and the sulfones compound can be efficiently synthesized by coupling with sulfinate under the condition of room temperature through visible light irradiation. The method has good substrate universalityand relatively mild reaction conditions, is not only a substitute for synthesizing sulfone compounds by coupling from simple substrates reported at present, but also broadens the new application of the polyacid salt in the field of photocatalysis.