312-95-8 Usage
General Description
Alpha,alpha,alpha,alpha',alpha'-pentafluoro-o-xylene is a highly fluorinated aromatic compound with the molecular formula C8HF5. It is a colorless liquid with a distinct, sweet odor and is insoluble in water. alpha,alpha,alpha,alpha',alpha'-pentafluoro-o-xylene is primarily used as a building block in the synthesis of other fluorinated compounds and materials, such as pharmaceuticals, agrochemicals, and advanced materials. Due to its highly fluorinated structure, alpha,alpha,alpha,alpha',alpha'-pentafluoro-o-xylene exhibits high thermal and chemical stability, making it useful in various industrial applications. However, it is important to handle this chemical with care, as it is considered hazardous and may have harmful effects on human health and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 312-95-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,1 and 2 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 312-95:
(5*3)+(4*1)+(3*2)+(2*9)+(1*5)=48
48 % 10 = 8
So 312-95-8 is a valid CAS Registry Number.
312-95-8Relevant articles and documents
Selective Late-Stage Hydrodefluorination of Trifluoromethylarenes: A Facile Access to Difluoromethylarenes
Munoz, Socrates B.,Ni, Chuanfa,Zhang, Zhe,Wang, Fang,Shao, Nan,Mathew, Thomas,Olah, George A.,Prakash, G. K. Surya
, p. 2322 - 2326 (2017/05/01)
A selective reductive monodefluorination reaction of trifluoromethyl arenes was developed. Mediated by magnesium metal, various difluoromethylated aromatics were accessed at room temperature in the presence of acetic acid. This protocol shows tolerance to a wide range of functional groups and it was applicable in late-stage hydrodefluorination of complex pharmaceutical compounds, affording the corresponding CF2H analogues and their deuterated (CF2D) counterparts.
METAL-CATALYZED COUPLING OF ARYL AND VINYL HALIDES WITH ALPHA, ALPHA-DIFLUOROCARBONYL COMPOUNDS
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Paragraph 0009; 00154-00155, (2014/10/18)
The coupling of aryl, heteroaryl, and vinyl halides with α,α-difluoroketones or silyl ethers or siylenol ethers of α,α-difluoroketones and α,α-difluoroamides and esters are described. Further derivatization of the coupling products (such as ketone cleavage and Baeyer-Villiger oxidation) is also described.
