31246-66-9

Basic information

• Product Name: cis,cis,trans-Diamminedichlorodihydroxoplatinum
• Synonyms: Oxoplatinum; Platinum,diamminedichlorodihydroxy-, stereoisomer (8CI); Oxo-Pt; Oxoplatin
• CAS NO: 31246-66-9
• Molecular Formula: Cl₂H₈N₂O₂Pt
• Molecular Weight: 334.0657
• Mol File: 31246-66-9.mol
• Article Data: 67

Chemical Properties

• CAS DataBase Reference: cis,cis,trans-Diamminedichlorodihydroxoplatinum(CAS DataBase Reference)
• NIST Chemistry Reference: cis,cis,trans-Diamminedichlorodihydroxoplatinum(31246-66-9)
• EPA Substance Registry System: cis,cis,trans-Diamminedichlorodihydroxoplatinum(31246-66-9)

Safety Data

• Hazardous Substances Data: 31246-66-9(Hazardous Substances Data)

Upstream product

• 26035-31-4 cisplatine 
• 7722-84-1 dihydrogen peroxide 
• 15663-27-1 cisplatin 
• 7732-18-5 water 
• 26035-31-4 transplatin 
• 7722-64-7 potassium permanganate 

Downstream Products

• 16893-05-3 cis-diaammineplatinum(IV) tetrachloride 
• 15663-27-1 cisplatin 
• 1613703-75-5 C₃₈H₃₆Cl₄N₄O₈Pt 

Relevant articles and documents

Berberine coupled cis-platinum compound as well as preparation method and application thereof

The invention relates to the technical field of pharmaceutical chemicals, and in particular, relates to a berberine coupled cis-platinum compound as well as a preparation method and application thereof. The invention provides a berberine coupled cis-platinum compound. The berberine coupled cis-platinum compound has a structure represented by a formula I in the specification. Results of the embodiment show that the berberine coupled cis-platinum compound provided by the invention can effectively inhibit the proliferation activity of intestinal cancer cells and significantly reduce the killing ability of cis-platinum to normal intestinal epithelial cells, and in-vivo experiments of mice prove that the berberine coupled cis-platinum compound has a better tumor inhibition effect than cis-platinum.

Quadrivalent platinum prodrug bendazac platinum, preparation thereof, and preparation methods and applications of prodrug and preparation

The invention belongs to the technical field of medicines, and particularly relates to a tetravalent platinum prodrug bendazac platinum, a preparation thereof, and preparation methods and applications of the prodrug and the preparation. The structural formula of the prodrug is shown in the specification. The preparation method of the prodrug comprises the following steps: (1) synthesizing hydroxyl platinum; (2) synthesizing bendazac platinum; and (3) purifying the bendazac platinum. The preparation method of the nano preparation comprises the following steps: (1) preparing a bendazac platinum solution; and (2) preparing the nano preparation by taking bovine serum albumin as a carrier. The tetravalent platinum prodrug bendazac platinum and the nano preparation thereof provided by the invention are good in water solubility, small in toxic and side effects and high in anti-tumor efficacy, can be passively targeted to a tumor site, can increase the drug uptake ability of tumor cells, and show a good anti-tumor effect, and the inhibition rates of the tetravalent platinum prodrug bendazac platinum to various tumors can be higher than 90%.

Low-toxicity Pt complex and preparation method and application thereof

The invention discloses a low-toxicity Pt complex, and belongs to the technical field of anticancer chemical drugs. The structure of the complex is as shown in a general formula (1) or a general formula (2), pterostilbene is introduced into the platinum (IV) complex, and the anti-tumor effect of the platinum complex is improved and the toxic and side effects of the platinum complex on normal cells are reduced by utilizing the anti-inflammatory and anti-oxidation double functions of the pterostilbene.