31271-88-2

Basic information

• Product Name: 6-chloro-1-tosyl-1H-indole
• Synonyms: 6-chloro-1-tosyl-1H-indole
• CAS NO: 31271-88-2
• Molecular Formula: C₁₅H₁₂ClNO₂S
• Molecular Weight: 305.77928
• Mol File: 31271-88-2.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-chloro-1-tosyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-1-tosyl-1H-indole(31271-88-2)
• EPA Substance Registry System: 6-chloro-1-tosyl-1H-indole(31271-88-2)

Safety Data

• Hazardous Substances Data: 31271-88-2(Hazardous Substances Data)

Upstream product

• 402822-78-0 N-allyl-N-p-toluenesulfonyl-5-chloro-2-ethenylaniline 
• 17422-33-2 6-chloroindole 
• 98-59-9 p-toluenesulfonyl chloride 
• 2123-27-5 2,4-dichlorostyrene 
• 127-65-1 chloroamine-T 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 6341-92-0 6-chloroisatin 

Downstream Products

• 17422-33-2 6-chloroindole 

Relevant articles and documents

A Series of 2-((1-Phenyl-1H-imidazol-5-yl)methyl)-1H-indoles as Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising therapeutic target in cancer immunotherapy and neurological disease. Thus, searching for highly active inhibitors for use in human cancers is now a focus of widespread research and development efforts. I

B(C6F5)3-Catalyzed Highly Chemoselective Reduction of Isatins: Synthesis of Indolin-3-ones and Indolines

A chemo- and site-selective reduction reaction of isatin derivatives using catalyst B(C6F5)3 and hydrosilanes is described. This transformation is operationally simple, proceeds under mild conditions, and is resistant to various functional groups. Thus, this efficient reaction using a combination of B(C6F5)3 and BnMe2SiH or B(C6F5)3 and Et2SiH2 could potentially be utilized to produce various indolin-3-ones and indolines, without the need for multistep procedures and metal catalysis conditions.

Method for removing sulfinyl group in heteroaryl compound

The invention discloses a method for removing a sulfinyl group in a heteroaryl compound. The method is characterized in that a heteroaryl cyclic sulfoxide compound represented by formula (Ia) or formula (Ib) and trimethylsilylphenyl trifluoromethanesulfonate represented by formula (II) used a substrate are reacted in the presence of cesium fluoride to obtain a sulfinyl group-removed heteroaryl compound represented by formula (IIIa) or (IIIb). The method can rapidly remove the sulfinyl group in the heteroaryl cyclic sulfoxide compound, does not need a metal catalyst with poor safety or highly toxic organic reagents, and is safe. The method has the advantages of mild conditions, strong compatibility with some sensitive benzenesulfonyl groups and Boc groups, simplicity in post-treatment, andsuitableness for industrial production.