3133-81-1

Basic information

• Product Name: methyl 3-methylbenzothiophene-2-carboxylate
• Synonyms: methyl 3-methylbenzothiophene-2-carboxylate;Benzo[b]thiophene-2-carboxylic acid,3-methyl-,methyl ester
• CAS NO: 3133-81-1
• Molecular Formula: C₁₁H₁₀O₂S
• Molecular Weight: 206.26
• Mol File: 3133-81-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 102-105°C
• Boiling Point: 313°C at 760 mmHg
• Flash Point: 143.1°C
• Appearance: /
• Density: 1.233g/cm³
• Vapor Pressure: 0.00051mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: methyl 3-methylbenzothiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-methylbenzothiophene-2-carboxylate(3133-81-1)
• EPA Substance Registry System: methyl 3-methylbenzothiophene-2-carboxylate(3133-81-1)

Safety Data

• Hazardous Substances Data: 3133-81-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 21, p. 1525, 1980 DOI: 10.1016/S0040-4039(00)92764-3

InChI:InChI=1/C11H10O2S/c1-7-8-5-3-4-6-9(8)14-10(7)11(12)13-2/h3-6H,1-2H3

Upstream product

• 72666-86-5 methyl 2-(phenylthio) acetoacetate 
• 28195-16-6 methyl (E)-3-hydroxy-2-(phenylthio)but-2-enoate 
• 67-56-1 methanol 
• 4755-81-1 methyl 2-chloroacetoacetate 
• 108-98-5 thiophenol 
• 450-95-3 2-fluoroacetophenone 
• 2365-48-2 Methyl thioglycolate 
• 3133-78-6 3-methylbenzo[b]thiophene-2-carboxylic acid 
• 445-27-2 2'-Fluoroacetophenone 
• 1455-18-1 3-methylbenzothiophene 
• 124-38-9 carbon dioxide 
• 74-88-4 methyl iodide 

Downstream Products

• 1346672-45-4 3-((3-bromo-2-methylphenylamino)methyl)benzo[b]thiophene-2-carboxylic acid 
• 1346672-47-6 2-(3-bromo-2-methylphenyl)-1H-benzothieno[2,3-c]pyrrol-3(2H)-one 
• 1346672-48-7 2-(2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-benzothieno[2,3-c]pyrrol-3(2H)-one 
• 1133435-54-7 3-{[(2,4-dimethoxybenzyl)ethoxycarbonylmethylamino]methyl}benzo[b]thiophene-2-carboxylic acid methyl ester 
• 1133435-55-8 2-(2,4-dimethoxybenzyl)-4-oxo-1,2,3,4,4a,9b-hexahydrobenzo[4,5]thieno[3,2-c]pyridine-3-carboxylic acid methyl ester 
• 3133-78-6 3-methylbenzo[b]thiophene-2-carboxylic acid 

Relevant articles and documents

Direct Carboxylation of Electron-Rich Heteroarenes Promoted by LiO-tBu with CsF and [18]Crown-6

We herein demonstrate that the combination of LiO-tBu, CsF, and [18]crown-6 efficiently promotes the direct C?H carboxylation of electron-rich heteroarenes (benzothiophene, thiophene, benzofuran, and furan derivatives). A variety of functional groups, including methyl, methoxy, halo, cyano, amide, and keto moieties, are compatible with this system. The reaction proceeds via the formation of a tert-butyl carbonate species.

[(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues

A new series of PHD (HIF prolyl 4-hydroxylase) inhibitors was designed based on the X-ray co-crystal structure of FG-2216. Using a lead generation process, a series of [(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)- amino]-acetic acid derivatives was developed as potent PHD2 inhibitors. This class of compounds also showed the ability to stabilize HIF-α, to stimulate EPO secretion in in vitro studies, and to increase hematocrit, red blood cell count, and hemoglobin levels in an animal efficacy study.

ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR

A compound represented by the formula (I) or a pharmacologically acceptable salt thereof is used as an activator of PPAR. wherein each of R1 and R2 is hydrogen, C1-8 alkyl, C1-8 alkyl substituted with halogen, or the like; each of R3, R4, R5, and R6 is h