313339-36-5

Basic information

• Product Name: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXAMIDE
• Synonyms: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXAMIDE
• CAS NO: 313339-36-5
• Molecular Formula: C₆H₅Cl₂N₃OS
• Molecular Weight: 238.0944
• Mol File: 313339-36-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 239-244°C
• Boiling Point: 351.378°C at 760 mmHg
• Flash Point: 166.308°C
• Appearance: /
• Density: 1.636g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.649
• CAS DataBase Reference: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXAMIDE(313339-36-5)
• EPA Substance Registry System: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXAMIDE(313339-36-5)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 313339-36-5(Hazardous Substances Data)

Usage

General Description

4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxamide is a chemical compound with a molecular formula C7H6Cl2N2OS. It is a pyrimidine derivative with two chlorine atoms attached to the 4 and 6 positions of the pyrimidine ring, and a methylthio group attached to the 2 position. The carboxamide group is attached to the 5 position of the pyrimidine ring. 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXAMIDE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has potential applications in the development of new medicines and crop protection products.

InChI:InChI=1/C6H5Cl2N3OS/c1-13-6-10-3(7)2(5(9)12)4(8)11-6/h1H3,(H2,9,12)

Upstream product

• 6299-25-8 4,6-Dichloro-2-(methylthio)pyrimidine 
• 1979-98-2 4,6-dihydroxy-2-methylmercaptopyrimidine 
• 313339-35-4 4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carboxylic acid 

Downstream Products

• 1388816-91-8 tert-butyl 4-(4-(5-carbamoyl-6-chloro-2-(methylthio)pyrimidin-4-ylamino)phenyl)piperazine-1-carboxylate 
• 1386949-15-0 tert-butyl 4-(4-(5-carbamoyl-6-chloro-2-(methylthio)pyrimidin-4-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1388816-87-2 tert-butyl 4-(4-(5-carbamoyl-6-hydrazinyl-2-(methylthio)pyrimidin-4-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1388816-88-3 tert-butyl 4-(4-(8-carbamoyl-5-(methylthio)-[1,2,4]triazolo[4,3-c]pyrimidin-7-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1388816-89-4 tert-butyl 4-(4-(8-carbamoyl-5-(2,6-dichlorobenzyl)-[1,2,4]triazolo[4,3-c]pyrimidin-7-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1388816-97-4 tert-butyl 4-(4-(8-carbamoyl-5-(methylthio)tetrazolo[1,5-c]pyrimidin-7-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1388816-99-6 tert-butyl 4-(4-(8-carbamoyl-5-(2,6-dichlorobenzyl)tetrazolo[1,5-c]pyrimidin-7-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1388817-20-6 tert-butyl 4-(4-(6-amino-5-carbamoyl-2-(methylthio)pyrimidin-4-ylamino)phenyl)piperazine-1-carboxylate 
• 1388817-21-7 tert-butyl 4-(4-(6-amino-5-carbamoyl-2-(2,6-dichlorobenzyl)pyrimidin-4-ylamino)phenyl)piperazine-1-carboxylate 
• 1388817-22-8 tert-butyl 4-(4-(8-carbamoyl-5-(2,6-dichlorobenzyl)imidazo[1,2-c]pyrimidin-7-ylamino)phenyl)piperazine-1-carboxylate 
• 1386952-42-6 5-(2,6-dichlorobenzyl)-7-{[4-(piperazin-1-yl)phenyl]amino}imidazo[1,2-c]pyrimidine-8-carboxamide 
• 1254057-15-2 4-chloro-2-(methylsulfanyl)-6-{[3-(methylsulfonyl)phenyl]amino}pyrimidine-5-carboxamide 
• 1254057-16-3 2-(methylsulfanyl)-4-{[3-(methylsulfonyl)phenyl]amino}-6-oxo-1,6-dihydropyrimidine-5-carboxamide 

Relevant articles and documents

BICYCLIC CARBOXAMIDE INHIBITORS OF KINASES

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein X1, X2, X3, X4, R1, R2, R3, A, B, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.