313467-78-6Relevant articles and documents
SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS
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Page/Page column 214-215, (2010/12/26)
The present invention provides a compound of formula I' or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Synthesis and SAR of thioester and thiol inhibitors of IMP-1 metallo-β-lactamase
Greenlee, Mark L.,Laub, Joanne B.,Balkovec, James M.,Hammond, Milton L.,Hammond, Gail G.,Pompliano, David L.,Epstein-Toney, Jeffrey H.
, p. 2549 - 2554 (2007/10/03)
Potent thioester and thiol inhibitors of IMP-1 metallo-β-lactamase have been synthesized employing a solid-phase Mitsunobu reaction as the key step.