314055-37-3

Basic information

• Product Name: N-(2-(trifluoromethyl)phenyl)pyrazine-2-carboxamide
• Synonyms: N-(2-(trifluoromethyl)phenyl)pyrazine-2-carboxamide
• CAS NO: 314055-37-3
• Molecular Weight: 267.21
• Mol File: 314055-37-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-(2-(trifluoromethyl)phenyl)pyrazine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(trifluoromethyl)phenyl)pyrazine-2-carboxamide(314055-37-3)
• EPA Substance Registry System: N-(2-(trifluoromethyl)phenyl)pyrazine-2-carboxamide(314055-37-3)

Safety Data

• Hazardous Substances Data: 314055-37-3(Hazardous Substances Data)

Upstream product

• 98-97-5 2-pyrazylcarboxylic acid 
• 34067-83-9 N-(phenyl)pyrazine-2-carboxamide 
• 2926-29-6 Langlois reagent 
• 62-53-3 aniline 
• 19847-10-0 pyrazinoyl chloride 
• 88-17-5 2-(trifluoromethyl)benzenamine 

Downstream Products

• 23779-99-9 floctafenine 
• 23779-97-7 4-chloro-8-(trifluoromethyl)quinoline 
• 450383-19-4 2,2-dimethyl-5-({[2-(trifluoromethyl)phenyl]amino}methylidene)-1,3-dioxane-4,6-dione 
• 93919-57-4 8-(trifluoromethyl)quinoline-4(1H)-one 
• 88-17-5 2-(trifluoromethyl)benzenamine 

Relevant articles and documents

Iron-catalyzed: Ortho trifluoromethylation of anilines via picolinamide assisted photoinduced C-H functionalization

A convenient, oxidant-free protocol was developed for the ortho trifluoromethylation of aniline via picolinamide assisted Fe-promoted C-H functionalization under ultraviolet irradiation. In this transformation acetone essentially acted as both a solvent to dissolve reactants and a low-cost radical initiator to efficiently generate a CF3 radical from Langlois' reagent. A broad substrate scope was tolerated and picolinamide bearing strong electron withdrawing groups also could be transformed into the corresponding products with acceptable yields. Furthermore, the value of this method has been highlighted via the efficient synthesis of the nonsteroidal anti-inflammatory drug floctafenine.

A metal-free picolinamide assisted electrochemical ortho-trifluoromethylation of arylamines

An eco-friendly and effective electrochemical process was developed for the ortho-trifluoromethylation of arylamines using CF3SO2Na as the trifluoromethyl source, affording the desired products in moderate to good yields with high regioselectivity under mild reaction conditions. Importantly, the requirement for both transition metals and oxidants utilized in previous methods were avoided. A radical mechanism was proposed on the basis of various control experiments.

Synthesis and antitubercular evaluation of N-Arylpyrazine and N,Na-Alkyl-diylpyrazine-2-carboxamide derivatives

Two series of pyrazinamide (PZA) derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. Some compounds exhibited minimum inhibitory concentration activity of 50-100 μg/mL, greater than the first line antituberculosis drug PZA in Alamar Blue assay (>100 μg/mL). The obtained activities can be considered promising results, which characterizes these compounds as good start points to development of new antitubercular agents.