3145-73-1

Basic information

• Product Name: 1-cyclohexyl-3-phenylprop-2-en-1-one
• Synonyms: 1-cyclohexyl-3-phenylprop-2-en-1-one
• CAS NO: 3145-73-1
• Molecular Weight: 214.307
• Mol File: 3145-73-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-cyclohexyl-3-phenylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclohexyl-3-phenylprop-2-en-1-one(3145-73-1)
• EPA Substance Registry System: 1-cyclohexyl-3-phenylprop-2-en-1-one(3145-73-1)

Safety Data

• Hazardous Substances Data: 3145-73-1(Hazardous Substances Data)

Upstream product

• 103-64-0 bromostyrene 
• 2043-61-0 cyclohexanecarbaldehyde 
• 4363-35-3 Dihydroxy-styryl-boran 
• 74628-02-7 C₁₁H₂₁O₅P 
• 100-52-7 benzaldehyde 
• 823-76-7 Cyclohexyl methyl ketone 

Downstream Products

• 1403934-76-8 (R)-4-hydroxy-3-(4-cyclohexyl-3-oxo-1-phenylbutyl)chromen-2-one 
• 43125-06-0 1-cyclohexyl-3-phenyl-1-propanone 

Relevant articles and documents

Facile Synthesis of Polysubstituted 2-Pyrones via TfOH-Mediated Ring Expansion of 2-Acylcyclopropane-1-carboxylates

A facile route to polysubstituted 2-pyrones from readily available 2-acylcyclopropane-1-aryl-1-carboxylates mediated by TfOH is reported. The strongly donating 1-aryl group is important for directing the C-C bond cleavage of the donor-acceptor cyclopropane ring, which then leads to the formation of the 2-pyrone ring through lactonization.

Direct C-H Arylation of Aldehydes by Merging Photocatalyzed Hydrogen Atom Transfer with Palladium Catalysis

Herein, we report that merging palladium catalysis with hydrogen atom transfer (HAT) photocatalysis enabled direct arylations and alkenylations of aldehyde C-H bonds, facilitating visible light-catalyzed construction of a variety of ketones. Tetrabutylammonium decatungstate and anthraquinone were found to act as synergistic HAT photocatalysts. Density functional theory calculations suggested a Pd0-PdII-PdIII-PdI-Pd0 pathway and revealed that regeneration of the Pd0 catalyst and the photocatalyst occurs simultaneously in the presence of KHCO3. This regeneration features a low energy barrier, promoting efficient coupling of the palladium catalytic cycle with the photocatalytic cycle. The work reported herein suggests great promise for further applications of HAT photocatalysis in palladium-catalyzed cross-coupling and C-H functionalization reactions to be successful.

Electrochemical 1,4-reduction of α,β-unsaturated ketones with methanol and ammonium chloride as hydrogen sources

A sustainable, chemoselective 1,4-reduction of α,β-unsaturated ketones by means of an electrochemical method is presented, wherein the extremely inexpensive ammonium chloride (NH4Cl) is applied as the only additive. The reaction proceeds smoothly in the air at ambient temperature. Mechanistic studies reveal that both NH4Cl and solvent methanol work as hydrogen donors.