31519-22-9

Basic information

• Product Name: 1,4-Dihydroxy-2-naphthoic acid
• Synonyms: 1,4-DIHYDROXY-2-NAPHTHALENECARBOXYLIC ACID;1,4-DIHYDROXY-2-NAPHTHALIC ACID;1,4-DIHYDROXY-2-NAPHTHOIC ACID;1,4-dihydroxy-2-naphthalenecarboxylicaci;1,4-Dihydroxy-2-naphtoic acid;1,4-Dohydroxy-2-naphthoic acid;1,4-dihydroxy-2-naphthoate;1 4-DIHYDROXY-2-NAPHTHOIC ACID 98%
• CAS NO: 31519-22-9
• Molecular Formula: C₁₁H₈O₄
• Molecular Weight: 204.18
• EINECS: 250-674-7
• Product Categories: Intermediates of Dyes and Pigments;Naphthalene derivatives;C11 to C12;Carbonyl Compounds;Carboxylic Acids
• Mol File: 31519-22-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 220 °C (dec.)(lit.)
• Boiling Point: 461.7 °C at 760 mmHg
• Flash Point: 247.1 °C
• Appearance: /
• Density: 1.535 g/cm³
• Vapor Pressure: 2.55E-09mmHg at 25°C
• Refractive Index: 1.761
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.89±0.30(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 1,4-Dihydroxy-2-naphthoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dihydroxy-2-naphthoic acid(31519-22-9)
• EPA Substance Registry System: 1,4-Dihydroxy-2-naphthoic acid(31519-22-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 31519-22-9(Hazardous Substances Data)

Usage

Description

1,4-Dihydroxy-2-naphthoic acid, derived from Propionibacterium freudenreichii, is a light yellow powder with unique chemical properties. It is a naphthoic acid that is 2-naphthoic acid substituted by hydroxy groups at positions 1 and 4. 1,4-Dihydroxy-2-naphthoic acid has gained attention for its potential therapeutic applications and its ability to promote the proliferation of Bifidobacterium.

Uses

Used in Pharmaceutical Industry:
1,4-Dihydroxy-2-naphthoic acid is used as a therapeutic agent for the treatment of psoriasis. It has demonstrated potential in promoting the proliferation of Bifidobacterium, which can contribute to the modulation of the skin microbiome and provide relief from psoriasis symptoms.
Used in Probiotic Applications:
In the field of probiotics, 1,4-Dihydroxy-2-naphthoic acid is used as a growth promoter for Bifidobacterium species. This application is particularly relevant in the development of probiotic products aimed at improving gut health and overall well-being. By enhancing the growth of beneficial bacteria, this compound can contribute to a balanced gut microbiota, which is essential for maintaining a healthy immune system and preventing various health issues.

InChI:InChI=1/C11H8O4/c12-9-5-8(11(14)15)10(13)7-4-2-1-3-6(7)9/h1-5,12-13H,(H,14,15)

Upstream product

• 59883-07-7 Diethyl 1,4-dihydroxynaphthalene-2,3-dicarboxylate 
• 86-48-6 1-hydroxy-2-naphthoic acid 
• 97226-61-4 C₃₂H₄₄N₇O₂₀P₃S 
• 124-38-9 carbon dioxide 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 84-66-2 Diethyl phthalate 
• 90-15-3 α-naphthol 
• 571-60-8 1,4-Dihydroxynaphthalene 
• 13588-28-8 di(propylene glycol) monomethyl ether 

Downstream Products

• 1010-60-2 2-chloro-1,4-naphthoquinone 
• 5697-00-7 1,4-diacetoxynaphthalene 
• 856075-00-8 4-acetoxy-1-hydroxy-[2]naphthoic acid 
• 93325-42-9 1,4-Naphthohydrochinon-2-carboxanilid 
• 950191-89-6 C₁₈H₉F₅O₄ 
• 55481-88-4 mollugin 
• 60657-93-4 methyl 6-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo-[h]chromene-5-carboxylate 
• 950191-66-9 C₂₉H₂₅F₅O₄ 
• 142182-54-5 rubilactone 
• 573-13-7 lapachenole 
• 1387566-90-6 3-[(3-fluorophenyl)amino]-1,4-dioxo-1,4-dihydronaphthalene-2-carboxylic acid 
• 1387566-83-7 1,4-dioxo-3-{[4-(propan-2-yl)phenyl]amino}-1,4-dihydronaphthalene-2-carboxylic acid 
• 1387566-92-8 3-[(4-chloro-2-fluorophenyl)amino]-1,4-dioxo-1,4-dihydronaphthalene-2-carboxylic acid 
• 1387566-87-1 3-((4-chlorophenyl)amino)-1,4-dioxo-1,4-dihydronaphthalene-2-carboxylic acid 

Relevant articles and documents

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Method for producing 1,4-dihydroxy-2-naphthoic acid

A method for producing 1,4-dihydroxy-2-naphthoic acid which comprises the steps of: subjecting 1,4-dihydroxynaphthalene into an alkali metal salt formation reaction in an organic medium capable of dissolving 1,4-dihydroxynaphthalene using an alkali metal alcoholate; and subjecting the salt formation reaction mixture to carboxylation using carbon dioxide gas.