31555-04-1

Basic information

• Product Name: 2-Butynoic acid, 4-hydroxy-, ethyl ester
• Synonyms: 2-Butynoic acid, 4-hydroxy-, ethyl ester;ethyl 4-hydroxybut-2-ynoate
• CAS NO: 31555-04-1
• Molecular Formula: C₆H₈O₃
• Molecular Weight: 128.12592
• Mol File: 31555-04-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 78 °C(Press: 0.5 Torr)
• Appearance: /
• Density: 1.145±0.06 g/cm3(Predicted)
• PKA: 13.14±0.10(Predicted)
• CAS DataBase Reference: 2-Butynoic acid, 4-hydroxy-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butynoic acid, 4-hydroxy-, ethyl ester(31555-04-1)
• EPA Substance Registry System: 2-Butynoic acid, 4-hydroxy-, ethyl ester(31555-04-1)

Safety Data

• Hazardous Substances Data: 31555-04-1(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 7218-52-2 4-hydroxy-2-butynoic acid 
• 31555-03-0 ethyl 4-((tetrahydro-2H-pyran-2-yl)oxy)but-2-ynoate 
• 207795-41-3 ethyl 4-(4-methoxybenzyloxy)but-2-ynoate 
• 50-00-0 formaldehyd 
• 623-47-2 propynoic acid ethyl ester 
• 541-41-3 chloroformic acid ethyl ester 
• 107-19-7 propargyl alcohol 

Downstream Products

• 81052-99-5 cleviolide 
• 3516-65-2 4-(4-methoxyphenyl)furan-2(5H)-one 
• 22248-27-7 3-(4-methoxyphenyl)furan-2(5H)-one 
• 119614-41-4 [5-Ethoxy-dihydro-furan-(3Z)-ylidene]-acetic acid ethyl ester 
• 1072106-97-8 C₂₀H₂₄O₇ 
• 1072107-08-4 C₂₀H₂₄O₇ 
• 1072106-99-0 C₂₁H₂₄O₉ 
• 1072107-09-5 C₂₁H₂₄O₉ 
• 1274892-67-9 E-[(phenylmethoxy)imino]butynoic acid ethyl ester 
• 1274892-66-8 Z-[(phenylmethoxy)imino]butynoic acid ethyl ester 
• 1274892-68-0 (2Z,4Z)-2-cyclohexyl-4-[(phenylmethoxy)imino]but-2-enoic acid ethyl ester 
• 1274892-69-1 3-methyl-2-[(phenylmethoxy)iminoethylidene]pentanoic acid ethyl ester 

Relevant articles and documents

Catalytic (3+2) Palladium-Aminoallyl Cycloaddition with Conjugated Dienes

We describe the design and application of tailored aminoallyl precursors for catalytic (3+2) cycloaddition with conjugated dienes via a Pd-aminoallyl intermediate. The new cycloaddition reactions override the conventional (4+3) selectivity of aminoallyl cation cycloaddition through a sequence of Pd-allyl transfer and ring closure. A variety of highly substituted or fused pyrrolidine rings were synthesized using the cycloaddition, and can further undergo [1,3] N-to-C rearrangement to five-membered carbocycles with a different palladium catalyst. The utility of the (3+2) cycloaddition is also demonstrated by the preparation of various derivatives from the bicyclic pyrrolidine products.

Ruthenium-catalyzed asymmetric [2 + 2] cycloadditions between chiral acyl camphorsultam-substituted alkynes and bicyclic alkenes

Ruthenium-catalyzed asymmetric [2 + 2] cycloadditions between chiral acyl camphorsultam-functionalized alkynes and bicyclic alkenes were examined, providing adducts with complete exo stereoselectivity in good overall yield and enantioselectivity (up to 99% and 166:1, respectively), as well as appreciable diastereoselectivity (up to 163:1). The diastereoselectivity showed dependence on the solvent and temperature, as well as on the substitution pattern of the reacting alkyne and bicyclic alkene components. In general, higher diastereoselectivities were observed for reactions conducted in ethereal solvents and at lower temperatures between N-propynoyl camphorsultams and bicyclic alkenes.

SUBSTITUTED PARA-BIPHENYLOXYMETHYL DIHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF

The present invention relates to a series of substituted para-biphenyloxymethyl dihydro oxazolopyrimidinones of formula (I) as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of