31575-15-2 Usage
Description
3-Ethyl-7-hydroxy-4,8-dimethyl-2H-chromen-2-one, commonly known as esculetin, is a naturally occurring coumarin derivative found in plants such as the American elm and the spotted cowbane. It is recognized for its antioxidant and anti-inflammatory properties, along with its potential therapeutic benefits in various medical conditions.
Uses
Used in Pharmaceutical Applications:
Esculetin is used as a therapeutic agent for its potential in treating conditions such as osteoporosis and neurodegenerative diseases due to its ability to inhibit blood clotting and its neuroprotective properties.
Used in Antimicrobial and Antifungal Applications:
Esculetin is utilized as an antimicrobial and antifungal agent, given its ability to combat various microorganisms, making it a candidate for the development of new pharmaceuticals in the field of infectious diseases.
Used in Antioxidant and Anti-Inflammatory Applications:
Esculetin is employed as an antioxidant and anti-inflammatory agent, leveraging its properties to protect against oxidative stress and reduce inflammation, which are important in the treatment and management of various diseases and conditions.
Used in Research and Development:
Esculetin is used in research and development for its potential applications in medicinal chemistry, where its properties are further explored for the development of new drugs and therapies.
Used in Industrial Applications:
Esculetin may also find use in industrial applications, such as in the development of nutraceuticals and cosmeceuticals, where its antioxidant and anti-inflammatory properties can be harnessed for health and beauty products.
Check Digit Verification of cas no
The CAS Registry Mumber 31575-15-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,5,7 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 31575-15:
(7*3)+(6*1)+(5*5)+(4*7)+(3*5)+(2*1)+(1*5)=102
102 % 10 = 2
So 31575-15-2 is a valid CAS Registry Number.
31575-15-2Relevant articles and documents
Design, synthesis, and antifungal evaluation of novel coumarin-pyrrole hybrids
Zhang, Shuguang,Tan, Xin,Liang, Chaogen,Zhang, Weihua
, p. 450 - 458 (2020/11/30)
A series of coumarin derivatives bearing a pyrrole scaffold were designed, prepared, and assessed for their in vitro antifungal activities against six phytopathogenic fungi. The antifungal activity screening results suggest that some synthesized hybrids exhibited potential fungicidal activities against the tested fungi. In particular, compounds 6j, 6k, 6o, 6p, and 6r displayed significant antifungal effects against Rhizoctorzia solani, and possessed EC50 values of 3.94, 7.75, 6.38, 6.25, and 7.67 μg/ mL, respectively. The above activities are more potent than the commercialized fungicide Boscalid (11.52 μg/mL) and Osthole (9.79 μg/mL). These results provide a significant reference for further rational design of coumarin-based fungicides.
Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives
Timonen, Juri M.,Nieminen, Riina M.,Sareila, Outi,Goulas, Antonis,Moilanen, Lauri J.,Haukka, Matti,Vainiotalo, Pirjo,Moilanen, Eeva,Aulaskari, Paula H.
supporting information; experimental part, p. 3845 - 3850 (2011/11/13)
A number of 7-hydroxycoumarins have been synthesised by Pechmann cyclisation using differently substituted resorcinols employing perchloric acid as the condensing agent. All the compounds have been characterised by analytical and spectroscopic methods. The anti-inflammatory properties were tested with LPS-induced inflammation in J774 macrophages. Expression of iNOS and COX-2 was determined by Western blot, NO by nitrite assay and IL-6 by ELISA analyses. Fifteen of the tested 7-hydroxycoumarins also inhibited IL-6 production but none of them had any major inhibitory effect on COX-2 expression.
