31575-75-4

Basic information

• Product Name: 2-BENZYLOXYBROMOBENZENE
• Synonyms: 1-(BENZYLOXY)-2-BROMOBENZENE;2-BENZYLOXYBROMOBENZENE;2-BROMOPHENYL BENZYL ETHER;benzyl 2-bromophenyl ether;Benzene, 1-broMo-2-(phenylMethoxy)-;1-BroMo-2-benzyloxybenzene;2-BroMophenol Benzyl Ether;Benzyloxy-1-broMobenzene
• CAS NO: 31575-75-4
• Molecular Formula: C₁₃H₁₁BrO
• Molecular Weight: 263.13
• Product Categories: Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds;alkyl bromide
• Mol File: 31575-75-4.mol
• Article Data: 56

Chemical Properties

• Boiling Point: 335.2 °C at 760 mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.382 g/cm³
• Vapor Pressure: 0.000236mmHg at 25°C
• Refractive Index: n20/D >1.6060(lit.)
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: 2-BENZYLOXYBROMOBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYLOXYBROMOBENZENE(31575-75-4)
• EPA Substance Registry System: 2-BENZYLOXYBROMOBENZENE(31575-75-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 31575-75-4(Hazardous Substances Data)

Usage

Description

2-BENZYLOXYBROMOBENZENE, also known as 2-(Benzyloxy)bromobenzene, is an organic compound characterized by a benzene ring with a bromine atom and a benzyloxy group attached to the 2nd position. It is a colorless oil with unique chemical properties that make it a versatile intermediate in the synthesis of various organic compounds.

Uses

Used in Pharmaceutical Industry:
2-BENZYLOXYBROMOBENZENE is used as a key intermediate in the synthesis of different inhibitors for pharmaceutical applications. Its unique structure allows for the development of compounds that can modulate biological pathways and target specific enzymes or receptors, leading to the creation of potential therapeutic agents.
Used in Chemical Synthesis:
In the chemical synthesis industry, 2-BENZYLOXYBROMOBENZENE serves as a valuable building block for the preparation of a wide range of organic compounds. Its reactivity and functional groups enable the formation of various derivatives, which can be further utilized in the synthesis of complex molecules for different applications.
Used in Research and Development:
2-BENZYLOXYBROMOBENZENE is also used in research and development settings to explore its potential applications and properties. Scientists and researchers can use this compound to investigate its reactivity, stability, and interactions with other molecules, leading to the discovery of new chemical reactions and applications.
Overall, 2-BENZYLOXYBROMOBENZENE is a versatile and valuable compound with applications in various industries, including pharmaceuticals, chemical synthesis, and research and development. Its unique structure and properties make it an essential component in the development of new compounds and the advancement of scientific knowledge.

InChI:InChI=1/C13H11BrO/c14-12-8-4-5-9-13(12)15-10-11-6-2-1-3-7-11/h1-9H,10H2

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 583-55-1 1-Bromo-2-iodobenzene 
• 100-51-6 benzyl alcohol 
• 1072-85-1 o-fluorobromobenzene 
• 584-08-7 potassium carbonate 
• 108-95-2 phenol 

Downstream Products

• 64323-19-9 1,5-Bis-(2-benzyloxy-phenyl)-1,5-bis-(2-methoxy-5-methyl-phenyl)-pentane-1,5-diol 
• 126503-51-3 (2R,3R,4R)-6-(2-Benzyloxy-phenyl)-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-3,4-dihydro-2H-pyran 
• 126503-54-6 (4R,5R,6R,4'R,5'R,6'R)-4,5,4',5'-Tetrakis-(tert-butyl-dimethyl-silanyloxy)-6,6'-bis-(tert-butyl-dimethyl-silanyloxymethyl)-5,6,5',6'-tetrahydro-4H,4'H-[2,2']bipyranyl 
• 133776-43-9 2'-(benzyloxy)-2-aminobenzophenone 
• 127898-38-8 (2-Benzyloxy-phenyl)-((1S,2S,3R,4R)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-methanol 
• 106047-20-5 4-(2-(benzyloxy)phenyl)pyridine 
• 137207-69-3 1-(2-Benzyloxy-phenyl)-1-hydroxy-4,6-dimethyl-3-oxo-1,3-dihydro-isobenzofuran-5-carboxylic acid ethyl ester 
• 151039-03-1 2-(2-benzyloxyphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol 
• 126503-51-3 1-C-(2-benzyloxyphenyl)-3,4,6-tri-O-(tert-butyldimethylsilyl)-D-glucal 
• 63613-45-6 2-Benzyloxy-β-(o-benzyloxyphenyl)-3',4,4',6-tetramethoxyhydrochalkon 
• 171364-77-5 Dicyclohexyl(2-hydroxyphenyl)phosphine 
• 252554-76-0 2-(diethoxyphosphoryl)phenyloxymethylbenzene 
• 264906-63-0 3β-(2-Benzyloxyphenyl)-5α-cholestan-3α-ol 
• 91-01-0 1,1-Diphenylmethanol 

Relevant articles and documents

Total synthesis of 7- and 8-oxygenated pyrano[3,2-a]carbazole and pyrano[2,3-a]carbazole alkaloids via boronic acid-catalyzed annulation of the pyran ring

The boronic acid-catalyzed annulation of citral opens up a short route to oxygenated cyclized monoterpenoid pyranocarbazole alkaloids. Thus, murrayamine-D is available in only three steps and 55% overall yield from the corresponding carbazole precursor.

SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS

Described herein are compounds of Formula (I), Formula (I-A), and Formula (I-B), solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing, Further described herein are methods of inhibiting NLRP3 using said compounds, and methods of and compositions useful in treating NLRP3-dependent disorders.

Improved Synthesis of MediPhos Ligands and Their Use in the Pd-Catalyzed Enantioselective N-Allylation of Glycine Esters

A new class of chiral C2-symmetric diphosphines (MediPhos) was recently shown to give superior results in the Pd-catalyzed asymmetric N-allylation of amino acid esters. We here describe a new, improved protocol for the preparation of such ligands through bidirectional SN2-coupling of a tartrate-derived ditosylate with 6-alkyl-2-bromophenols followed by double lithiation/phosphanylation. This method gave access to a series of nine ligands with branched alkyl substituents, which were benchmarked in the enantioselective Pd-catalyzed N-allylation of tert-butyl glycinate with racemic (E)-2,8-dimethylnona-5-en-4-yl methyl carbonate (up to 95 % ee). In addition, the analogous transformation of tert-butyl glycinate with methyl (E)-nona-5-en-4-yl carbonate was optimized. The obtained allylic amines were then used in the stereoselective synthesis of the conformationally restricted proline-derived dipeptide analogs ProM-17 and ProM-21.