31576-51-9

Basic information

• Product Name: 2-(2-Methoxyethoxy)ethanamine
• Synonyms: 2-(2-Methoxyethoxy)ethanamine;MeO-EG(2)-NH2;EthanaMine, 2-(2-Methoxyethoxy)-;mPEG2-NH2;m-PEG2-amine;Di(ethylene glycol) methyl ether amine;2-(2-Methoxyethoxy)ethylamine;NH2-PEG2-OME
• CAS NO: 31576-51-9
• Molecular Formula: C₅H₁₃NO₂
• Molecular Weight: 119.16222
• Product Categories: MeO-PEG-NH2
• Mol File: 31576-51-9.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 163.7°C at 760 mmHg
• Flash Point: 54.1°C
• Appearance: /
• Density: 0.934g/cm³
• Vapor Pressure: 2.03mmHg at 25°C
• Refractive Index: 1.419
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 8.75±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 2-(2-Methoxyethoxy)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Methoxyethoxy)ethanamine(31576-51-9)
• EPA Substance Registry System: 2-(2-Methoxyethoxy)ethanamine(31576-51-9)

Safety Data

• RIDADR: 3265
• HazardClass: 8
• PackingGroup: Ⅱ
• Hazardous Substances Data: 31576-51-9(Hazardous Substances Data)

Usage

Description

2-(2-Methoxyethoxy)ethanamine, also known as m-PEG2-amine, is a PEG (polyethylene glycol) linker containing an amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), and other functional groups. The hydrophilic PEG spacer increases solubility in aqueous media, making it a versatile building block for various applications.

Uses

Used in Organic Synthesis:
2-(2-Methoxyethoxy)ethanamine is used as a reactant in the preparation of cyclopeptoids, which are cyclic peptides with diverse biological activities and potential applications in drug discovery and development.
Used in Phase-Transfer Catalysis:
2-(2-Methoxyethoxy)ethanamine is used as a phase-transfer catalyst to facilitate reactions between organic and inorganic compounds, particularly in the synthesis of various organic compounds.
Used in Drug Delivery Systems:
2-(2-Methoxyethoxy)ethanamine can be used as a building block in the development of drug delivery systems, taking advantage of its reactivity and hydrophilic properties to improve the solubility and bioavailability of therapeutic agents.
Used in Bioconjugation:
The reactive amino group of 2-(2-Methoxyethoxy)ethanamine allows it to be used in bioconjugation, where it can be used to attach biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces for various applications, including diagnostics, therapeutics, and biosensors.
Used in Polymer Science:
2-(2-Methoxyethoxy)ethanamine can be used as a monomer or building block in the synthesis of functional polymers with tailored properties, such as stimuli-responsive materials, hydrogels, or self-assembling systems for various applications in materials science and biotechnology.

InChI:InChI=1/C5H13NO2/c1-7-4-5-8-3-2-6/h2-6H2,1H3

Upstream product

• 52808-36-3 1-chloro-2-(2-methoxyethoxy)ethane 
• 215181-61-6 1-(1-ethoxy-2-azido)-2-methoxyethane 
• 111-77-3 2-(2-methoxyethoxy)ethyl alcohol 
• 50586-80-6 toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester 
• 54149-17-6 2-bromoethyl 2-methoxyethyl ether 
• 684221-36-1 N-(tert-butyloxycarbonyl)-2-(2-methoxyethoxy)ethylamine 
• 179820-15-6 2-(2-(2-methoxyethoxy)ethyl)isoindoline-1,3-dione 
• 194941-16-7 benzenesulfonic acid 2-(2-methoxy-ethoxy)-ethyl ester 
• 60696-83-5 methanesulfonic acid 2-(2-methoxyethoxy)ethyl ester 

Downstream Products

• 756902-17-7 N-[2-(2-methoxyethoxy)ethyl]-4,5-dimethyl-2-nitroaniline 
• 1027220-25-2 {5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulfanyl]-pentyl}-[2-(2-methoxy-ethoxy)-ethyl]-amine 
• 162933-18-8 4,5-bis<4-(dimethylamino)phenyl>-2-<<5-<<2-(2-methoxyethoxy)ethyl>amino>pentyl>thio>-1H-imidazole 
• 162933-11-1 N-<2-(2-methoxyethoxy)ethyl>-5-<<4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl>thio>pentanamide 
• 162933-14-4 N-<2-(2-methoxymethoxy)ethyl>5-<<4,5-bis(4-dimethylamino)-1H-imidazol-2-yl>thio>pentanamide 
• 1187213-97-3 N-((6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-2-(2-methoxyethoxy)ethanamine 
• 1234145-84-6 SylA-PEG₂ 
• 1175086-32-4 [1-(3,5-Dimethyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidine-4-yl]-[2-(2-methoxy-ethoxy)-ethyl]-amine 
• 1339046-84-2 N₁-[2-(2-methoxy-ethoxy)-ethyl]-4-nitro-benzene-1,3-diamine 
• 1339046-85-3 [2-(4-amino-3-nitro-phenyl)-1H-benzoimidazol-5-yl]-[2-(2-methoxy-ethoxy)-ethyl]-amine 
• 1339046-88-6 4-{5-[2-(2-methoxy-ethoxy)-ethylamino]-1H-benzoimidazol-2-yl}-benzene-1,2-diamine 
• 1287239-86-4 (S)-1-(2-(2-methoxyethoxy)ethyl)-3-(1-phenylethyl)thiourea 
• 1257585-50-4 C₁₈H₂₈N₂O₅ 
• 1257692-51-5 C₁₃H₂₀N₂O₃ 

Relevant articles and documents

Competitive intramolecular hydrogen bonding in oligo(ethylene oxide) substituted quadruple hydrogen bonded systems

(Figure Presented) A series of oligo(ethylene oxide) (oligoEO) substituted 2-ureido-pyrimidinones (UPy), differing in the number of ethylene oxide units and the length of the aliphatic spacer connecting the oligoEO side chain with the UPy group, have been prepared. It was found that variation in these structural parameters strongly influences the dimerization constant (K dim) of theUPy dimer and the association constant (Ka) of UPy with 2,7-diamido-1,8-naphthyridine (NaPy) in chloroform. By analyzing the relation between dimerization strength, length of aliphatic spacer, and the number of EO units in the oligoEO chain, we present strong evidence that the reduction in hydrogen bond strength is caused by competitive intramolecular hydrogen bonding of the ether atoms of the oligoEO chain to the hydrogen bond donors of the UPy unit.

Self-Assembly Can Direct Dynamic Covalent Bond Formation toward Diversity or Specificity

With the advent of reversible covalent chemistry the study of the interplay between covalent bond formation and noncovalent interactions has become increasingly relevant. Here we report that the interplay between reversible disulfide chemistry and self-assembly can give rise either to molecular diversity, i.e., the emergence of a unprecedentedly large range of macrocycles or to molecular specificity, i.e., the autocatalytic emergence of a single species. The two phenomena are the result of two different modes of self-assembly, demonstrating that control over self-assembly pathways can enable control over covalent bond formation.

ALKYNYL INDAZOLE DERIVATIVE AND USE THEREOF

The main object of the present invention is to provide a novel compound which has a VEGF receptor tyrosine kinase inhibitory activity and is useful as an active ingredient for the treatment of diseases accompanying angiogenesis or edema, for example, age-related macular degeneration or the like. The present invention includes, for example, an alkynyl indazole derivative represented by the following general formula (I), a pharmaceutical acceptable salt thereof, and a medicine containing thereof.