31591-86-3 Usage
General Description
1-H-pyrazolo[3,4-b]pyridin-4-ol, also known as PNU-282987, is a chemical compound with potential pharmaceutical applications. It is a selective agonist for the α7 nicotinic acetylcholine receptor, which is involved in various physiological and pathological processes, including cognition, memory, and neuroprotection. PNU-282987 has been extensively studied for its potential use in treating cognitive impairments associated with neurodegenerative diseases, such as Alzheimer's disease. It has also been investigated for its potential in treating psychiatric disorders, pain management, and inflammation. Its selective binding to the α7 receptor makes it a promising candidate for the development of new drugs targeting this receptor for therapeutic purposes.
Check Digit Verification of cas no
The CAS Registry Mumber 31591-86-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,5,9 and 1 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 31591-86:
(7*3)+(6*1)+(5*5)+(4*9)+(3*1)+(2*8)+(1*6)=113
113 % 10 = 3
So 31591-86-3 is a valid CAS Registry Number.
31591-86-3Relevant articles and documents
Gas-phase synthesis of pyrazolo[3,4- b ]pyridin-4-ones
Mackay, Martha,Nortcliffe, Andrew,McNab, Hamish,Hulme, Alison N.
, p. 242 - 248 (2015/05/05)
Flash vacuum pyrolysis (FVP) at 500-600 °C of 1-substituted pyrazolylaminomethylene derivatives of Meldrum's acid provides 1-substituted pyrazolo[3,4-b]pyridin-4-ones in high yields. If the 1-substituent is a tert-butyl group, FVP at 750-850 °C causes elimination of 2-methyl-1-propene to give the parent pyrazolo[3,4-b]pyridin-4-one.
