316124-88-6

Basic information

• Product Name: 4-methyl-N-(2-isobutyl-6-hydroxy-8-quinolyl)benzenesulfonamide
• Synonyms: 4-methyl-N-(2-isobutyl-6-hydroxy-8-quinolyl)benzenesulfonamide
• CAS NO: 316124-88-6
• Molecular Weight: 370.472
• Mol File: 316124-88-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-methyl-N-(2-isobutyl-6-hydroxy-8-quinolyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-(2-isobutyl-6-hydroxy-8-quinolyl)benzenesulfonamide(316124-88-6)
• EPA Substance Registry System: 4-methyl-N-(2-isobutyl-6-hydroxy-8-quinolyl)benzenesulfonamide(316124-88-6)

Safety Data

• Hazardous Substances Data: 316124-88-6(Hazardous Substances Data)

Upstream product

• 73630-19-0 2-iodomethyl-6-methoxy-8-nitroquinoline 
• 316124-84-2 8-amino-2-isobutyl-6-methoxyquinoline 
• 133378-39-9 6-methoxy-8-nitroquinolinecarbaldehyde 
• 54232-06-3 6-methoxy-2-methyl-8-nitroquinoline 
• 316124-85-3 4-metyl-N-(2-isobutyl-6-methoxy-8-quinolyl)benzenesulfonamide 

Downstream Products

• 316124-91-1 ethyl 2-(2-isobutyl-6-quinolyloxy-8-p-toluenesulfonamido)acetate 

Relevant articles and documents

The synthesis and fluorescent properties of analogues of the zinc(II) specific fluorophore zinquin ester

The synthesis and fluorescent properties in the absence and presence of zinc(II) of a range of 2-substituted derivatives of N-(6-methoxy-2-methyl-8-quinolyl)-4-methylbenzenesulfonamide are described. These analogues formed complexes with zinc(II) as indicated by a bathochromic shift in their UV/vis spectra. Analogues with isobutenyl and isobutyl side chains at the 2-position formed fluorescent complexes whose fluorescence was stronger than that of the 2-methyl-containing parent. These derivatives were converted, via conversion to the phenol with boron tribromide and reaction with ethyl bromoacetate, to systems with ester-containing side chains analogous to zinquin ester, a specific cellular fluorophore for zinc(II). All of these ester derivatives formed complexes with zinc(II) resulting in a bathochomic shift in their UV/vis spectra. Compounds with isobutyl, isobutenyl, and styryl side chains exhibited increased fluorescence compared to that of zinquin ester in the presence of zinc(II). The compound with the 2-isobutyl side chain was more selective in its fluorescence for zinc(II) over cadmium(II) compared to zinquin ester.