3167-07-5

Basic information

• Product Name: BenzeneethanaMine, 2-Methoxy-, (Hydrochloride)
• Synonyms: 2-MethoxyphenylethylaMine (Hydrochloride);BenzeneethanaMine, 2-Methoxy-, (Hydrochloride)
• CAS NO: 3167-07-5
• Molecular Formula: C₉H₁₃NO*ClH
• Molecular Weight: 187.66656
• Mol File: 3167-07-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 235 °C at 760 mmHg
• Flash Point: 95 °C
• Appearance: /
• Density: 1.008 g/cm³
• CAS DataBase Reference: BenzeneethanaMine, 2-Methoxy-, (Hydrochloride)(CAS DataBase Reference)
• NIST Chemistry Reference: BenzeneethanaMine, 2-Methoxy-, (Hydrochloride)(3167-07-5)
• EPA Substance Registry System: BenzeneethanaMine, 2-Methoxy-, (Hydrochloride)(3167-07-5)

Safety Data

• Hazardous Substances Data: 3167-07-5(Hazardous Substances Data)

Usage

General Description

Benzeneethanamine, 2-methoxy-, hydrochloride is a chemical compound used primarily as an antidepressant medication. It belongs to the class of drugs known as monoamine oxidase inhibitors (MAOIs), which work by increasing the levels of certain chemicals in the brain that regulate mood and emotional wellbeing. BenzeneethanaMine, 2-Methoxy-, (Hydrochloride) is commonly used to treat depression and anxiety disorders, as well as other mood-related conditions. It is typically administered in the form of oral tablets and should be taken under the supervision of a healthcare professional due to potential interactions with other medications and dietary restrictions.

Upstream product

• 148715-52-0 3-<(E)-<2-(2-methoxyphenyl)ethenyl>>-4,5-diphenyl-2(3H)oxazolone 
• 7035-03-2 2-methoxy-benzeneacetonitrile 

Relevant articles and documents

Phosphine-Free Manganese Catalyst Enables Selective Transfer Hydrogenation of Nitriles to Primary and Secondary Amines Using Ammonia-Borane

Herein we report the synthesis of primary and secondary amines by nitrile hydrogenation, employing a borrowing hydrogenation strategy. A class of phosphine-free manganese(I) complexes bearing sulfur side arms catalyzed the reaction under mild reaction conditions, where ammonia-borane is used as the source of hydrogen. The synthetic protocol is chemodivergent, as the final product is either primary or secondary amine, which can be controlled by changing the catalyst structure and the polarity of the reaction medium. The significant advantage of this method is that the protocol operates without externally added base or other additives as well as obviates the use of high-pressure dihydrogen gas required for other nitrile hydrogenation reactions. Utilizing this method, a wide variety of primary and symmetric and asymmetric secondary amines were synthesized in high yields. A mechanistic study involving kinetic experiments and high-level DFT computations revealed that both outer-sphere dehydrogenation and inner-sphere hydrogenation were predominantly operative in the catalytic cycle.

Phenethylamines via Heck Arylation of a New Vinylamine Equivalent

A new vinylamine equivalent, N-vinyloxazolone 3, has been prepared in three steps and shown to undergo Heck arylation with a variety of substrates.The Heck adducts thus obtained are then converted in one step and high yield to phenethylamine hydrochlorides.As a general synthetic method for preparation of substituted phenethylamines, use of this new reagent is shown to be superior to N-vinylphthalimide in number of steps, regiospecificity, and chemical yield.