3167-63-3 Usage
Description
DIETHYL (CHLOROMETHYL)PHOSPHONATE is a clear colorless to light yellow liquid that serves as a versatile reactant in various chemical reactions and synthesis processes.
Uses
Used in Organic Synthesis:
DIETHYL (CHLOROMETHYL)PHOSPHONATE is used as a reactant for subsequent alkylation after nucleophilic substitution, enabling the formation of a wide range of organic compounds.
Used in One-Pot Alkylation-Boration:
DIETHYL (CHLOROMETHYL)PHOSPHONATE is used as a reactant in one-pot alkylation-boration of α-haloalkylphosphonates, allowing for the efficient synthesis of various organic molecules.
Used in Synthesis of Cyclopentane and Pyrrolidine Derivatives:
DIETHYL (CHLOROMETHYL)PHOSPHONATE is used as a reactant for the synthesis of cyclopentane and pyrrolidine derivatives via regioselective insertion reactions, contributing to the development of complex organic structures.
Used in Phosphorylation Reactions:
DIETHYL (CHLOROMETHYL)PHOSPHONATE is used as a reactant in phosphorylation reactions, leading to the formation of P-containing cyclopropanes and expanding the scope of phosphorus-containing organic compounds.
Used in Wadsworth-Emmons Reactions:
DIETHYL (CHLOROMETHYL)PHOSPHONATE is used as a reactant in Wadsworth-Emmons reactions, facilitating the synthesis of alkenes and providing a valuable method for carbon-carbon bond formation.
Used in Ring Expansion of Zirconacycles:
DIETHYL (CHLOROMETHYL)PHOSPHONATE is used as a reactant in the ring expansion of zirconacycles via carbenoid insertion, allowing for the synthesis of larger ring systems and the development of novel organic compounds.
Synthesis Reference(s)
Tetrahedron Letters, 28, p. 3799, 1987 DOI: 10.1016/S0040-4039(00)96387-1
Check Digit Verification of cas no
The CAS Registry Mumber 3167-63-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,1,6 and 7 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 3167-63:
(6*3)+(5*1)+(4*6)+(3*7)+(2*6)+(1*3)=83
83 % 10 = 3
So 3167-63-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H12ClO3P/c1-3-8-10(7,5-6)9-4-2/h3-5H2,1-2H3
3167-63-3Relevant articles and documents
A Convenient Synthesis of Diethyl 1-Chloroalkylphosphonates
Gajda, Tadeusz
, p. 717 - 718 (1990)
The title compounds were obtained in high yield by the reaction of diethyl 1-hydroxyalkylphosphonates with triphenylphosphine carbon tetrachloride.
SYNTHESIS OF INTERMEDIATES USED IN THE MANUFACTURE OF ANTI-HIV AGENTS
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Page/Page column 25-26, (2016/11/21)
The present invention relates to a process of preparing intermediates of Formula (I). The process comprises of reacting compound of Formula (III) with compound of Formula (V) in the presence of a solvent selected from an alcohol, ether or water to form compound of Formula (I) wherein, R1 is selected from –NH2, Cl, Br, NHCOR", wherein R" is alkyl, aryl, Schiff's base of formula N=CHR', wherein R' is alkyl or aryl; R2 is selected from H, alkyl; R3 and R4, each independently is H; R5 and R6, each independently is H, alkyl; R7 is H, alkyl; and R8 is H, alkyl.
Reactions of α-boranophosphorus compounds with electrophiles: Alkylation, acylation, and other reactions
Antczak, Monika I.,Montchamp, Jean-Luc
supporting information; experimental part, p. 3758 - 3766 (2009/11/30)
(Chemical Equation Presented) The homologation of phosphorus carbenoids with organoboranes leads to α-boranophosphorus compounds, which can be further functionalized through reactions with various electrophiles, either directly or after activation to the
