31785-60-1 Usage
Description
1-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-one, also known as NQDQ, is a heterocyclic chemical compound belonging to the class of quinazolinone derivatives. It features a naphthalene ring fused with a quinazolinone ring, endowing it with unique structural and potential medicinal properties. NQDQ has demonstrated promising bioactivity, making it a valuable target for pharmaceutical research and development.
Uses
Used in Pharmaceutical Industry:
1-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-one is used as a pharmaceutical agent for its diverse bioactivity, including anticancer, antifungal, and anti-inflammatory properties. Its unique structure allows it to target various biological pathways and mechanisms, offering potential therapeutic benefits in treating a range of diseases and conditions.
Used in Cancer Research:
In cancer research, NQDQ is utilized as an anticancer agent, where its bioactivity has shown potential in inhibiting the growth and proliferation of cancer cells. Its ability to target multiple cellular pathways makes it a promising candidate for further investigation into its anticancer properties and possible development as a therapeutic agent.
Used in Antifungal Applications:
NQDQ is also used as an antifungal agent, where its bioactivity has demonstrated effectiveness against various fungal species. This makes it a potential candidate for the development of new antifungal drugs to combat fungal infections.
Used in Anti-inflammatory Research:
In the realm of anti-inflammatory research, NQDQ is employed to study its potential to alleviate inflammation. Its demonstrated bioactivity in this area suggests that it could be a valuable component in the development of new anti-inflammatory medications.
Overall, the diverse applications of 1-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-one across various fields of medicine highlight its potential as a versatile and promising compound for future pharmaceutical development.
Check Digit Verification of cas no
The CAS Registry Mumber 31785-60-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,7,8 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 31785-60:
(7*3)+(6*1)+(5*7)+(4*8)+(3*5)+(2*6)+(1*0)=121
121 % 10 = 1
So 31785-60-1 is a valid CAS Registry Number.
31785-60-1Relevant articles and documents
Potassium tert-Butoxide Promoted Synthesis of Dihydroquinazolinones
Basak, Soumya Jyoti,Dash, Jyotirmayee,Ghosh, Tridev,Mandal, Indradip
supporting information, p. 14695 - 14704 (2021/10/20)
We herein report an efficient synthetic protocol to access heterocyclic dihydroquinazolinones by a transition-metal-free process, involving the reaction of 2-aminobenzonitriles with aldehydes in the presence of KOtBu. The method is compatible with aromatic ketones providing 2,2-disubstituted dihydroquinazolinones in high yields. This reaction proceeds feasibly at room temperature and features a broad substrate scope and tolerance to a range of functional groups. The mechanism follows a radical pathway.
Green and efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their anthelmintic studies
Kharmawlong, George Kupar,Nongrum, Ridaphun,Chhetri, Bhusan,Rani, Jims World Star,Rahman, Noimur,Yadav, Arun Kumar,Nongkhlaw, Rishanlang
supporting information, p. 2683 - 2695 (2019/08/07)
A facile and highly efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones derivatives has been developed by the condensation of anthranilamide with aldehydes using sulfonic acid functionalized l-Proline?Fe3O4 nanoparticles as a catalyst. The advantages of this protocol are easy recovery and reusability of the catalyst besides simple work-up procedure and short reaction time. In addition, the anthelmintic activities of some selective compounds were investigated and it was found that 2-phenyl-2,3-dihydroquinazolin-4(1H)-one exhibited profound anthelmintic activity against two helminth models.
Recyclable [Ce(l -Pro) 2 ] 2 (Oxa) used as Heterogeneous Catalyst: One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1 H)-ones in Ethanol
Katla, Ramesh,Chowrasia, Rakhi,Da Silva, Caren D. G.,De Oliveira, Aline R.,Dos Santos, Beatriz F.,Domingues, Nelson L. C.
supporting information, p. 5143 - 5148 (2017/10/07)
[Ce(l -Pro) 2 ] 2 (Oxa) was used as a recyclable heterogeneous catalyst under mild conditions for the preparation of 2-aryl-2,3-dihydroquinazolin-4(1 H)-one derivatives. The one-pot protocol proceeds in ethanol using anthranilamide with several aldehydes at 50-55 °C. The catalyst can be recycled and reused three cycles without significant loss of catalytic activity.
