31824-93-8

Basic information

• Product Name: Acetic acid, [4-(3-oxo-3-phenyl-1-propenyl)phenoxy]-
• CAS NO: 31824-93-8
• Molecular Formula: C17H14O4
• Molecular Weight: 282.296
• Mol File: 31824-93-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Acetic acid, [4-(3-oxo-3-phenyl-1-propenyl)phenoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, [4-(3-oxo-3-phenyl-1-propenyl)phenoxy]-(31824-93-8)
• EPA Substance Registry System: Acetic acid, [4-(3-oxo-3-phenyl-1-propenyl)phenoxy]-(31824-93-8)

Safety Data

• Hazardous Substances Data: 31824-93-8(Hazardous Substances Data)

Upstream product

• 51264-69-8 ethyl 2-(4-formylphenoxy)acetate 
• 20426-12-4 (E)-3-(4-hydroxyphenyl)-1-phenyl-2-propen-1-one 
• 123-08-0 4-hydroxy-benzaldehyde 
• 98-86-2 acetophenone 
• 123228-89-7 ethyl {4-[(1E)-3-oxo-3-phenylprop-1-enyl]phenoxy}acetate 
• 22042-71-3 (4-formylphenoxy)acetic acid 
• 38239-55-3 4-hydroxychalcone 

Downstream Products

• 1373337-34-8 2-(4-(2-amino-6-phenylpyrimidin-4-yl)phenoxy)acetic acid 

Relevant articles and documents

Chalcone aryloxyacetamide compound as well as preparation method and application thereof

The invention relates to the field of pharmaceutical chemistry, in particular to a chalcone aryloxyacetamide compound (I) or (II) and a preparation method thereof. As proved by a pharmacodynamic test,the compound has the effects of reducing blood glucose, reducing triglyceride and reducing cholesterol, and can be used for treating abnormal glucolipid metabolism and obesity. A general formula of the compound is shown in the description.

Design, synthesis, and biological evaluation of chalcone- containing shikonin derivatives as inhibitors of tubulin polymerization

The biological importance of microtubules in mitosis makes them an interesting target for the development of anticancer agents. In this study, a series of novel chalcone-containing shikonin derivatives was designed, synthesized, and evaluated for biologic

Synthesis and in vitro antiplasmodial evaluation of 7-chloroquinoline-chalcone and 7-chloroquinoline-ferrocenylchalcone conjugates

Abstract The manuscript describes the synthesis of novel amide tethered 7-chloroquinoline-chalcone and 7-chloroquinoline-ferrocenylchalcone bifunctional hybrids and their evaluation as antimalarial agents against W2 resistant strain of Plasmodium falciparum. The antiplasmodial activity of 7-chloroquinoline-ferrocenylchalcones was found to be less than their corresponding simple chalcone conjugates. The presence of a methoxy substituent at para position of ring B on chalcones and longer alkyl chain length markedly improved the antiplasmodial profiles of the synthesized scaffolds with the most potent of the test compound exhibiting an IC50 value of 17.8 nM. Synthesis of 7-chloroquinoline-chalcone and 7-chloroquinoline-ferrocenylchalcone conjugates.Antimalarial potency of synthesized conjugates was evaluated against W2 strain.Most potent and non-cytotoxic conjugate exhibited IC50 of 17.8 nM.