31910-18-6Relevant articles and documents
Novel molecular targeting anti-tumor aza-steroid derivative based on lipid toxicity and preparation and application thereof
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Paragraph 0178; 0180; 0181; 0192; 0221, (2021/08/19)
The invention provides a novel molecular targeting anti-tumor aza-steroid derivative based on lipid toxicity and a preparation method and application thereof, and belongs to the field of chemical medicines. The derivative is a compound as shown in a formula I, or a salt thereof, or a stereoisomer thereof. The compound is low in toxicity or basically non-toxic to normal cells, has an obvious inhibition effect to tumor cell lines, particularly has good lipid toxicity selectivity to tumor cells such as liver cancer, lung cancer and the like in vivo, and has an obvious inhibition effect; meanwhile, the compound can effectively activate SREBP1 and PPAR gamma, inhibit lipid transport MTTP, cause lipid aggregation in tumor cells and cause lipid toxicity of the tumor cells. The compound can be used for treating liver cancer, lung cancer and the like in a molecular targeting manner, is low in toxicity or even non-toxic, and has a good application prospect.
NS3/4A protease inhibitor intermediate as well as synthesis method and application thereof
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Paragraph 0034-0054; 0076; 0078; 0080; 0082; 0084; 0086, (2020/04/22)
The invention belongs to the technical field of medicine, and particularly relates to an NS3/4A protease inhibitor intermediate as well as a synthesis method and application thereof. The synthesis method comprises the following steps: taking 4-methoxy-o-p
HEPATITIS C VIRUS NS3/4A PROTEASE INHIBITORS
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Paragraph 00192, (2019/01/11)
The invention provides novel classes of HCV therapeutics that are orally available, safe and effective HCV NS3/4A protease inhibitors and are less susceptible to drug resistance than existing therapeutics. The invention also relates to pharmaceutical composition of these compounds and methods of preparation and use thereof.