31928-20-8Relevant articles and documents
INDAZOLE DERIVATIVES AS INHIBITORS OF SARM1
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Paragraph 0365-0366, (2021/10/15)
The present disclosure provides compounds of formula (I) and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity
Kirby, Ilsa T.,Schultz, Carsten,Cohen, Michael S.,Arnold, Moriah R.,Vermehren-Schmaedick, Anke,Sreenivasan, Raashi,Kojic, Ana,Thorsell, Ann-Gerd,Karlberg, Tobias,Schüler, Herwig
, p. 1547 - 1553 (2019/01/24)
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Asymmetric Synthesis of Fused Polycyclic Indazoles through Aminocatalyzed Aza-Michael Addition/Intramolecular Cyclization
Giardinetti, Maxime,Marrot, Jér?me,Moreau, Xavier,Coeffard, Vincent,Greck, Christine
, p. 6855 - 6861 (2016/08/16)
The first example of an asymmetric aminocatalyzed aza-Michael addition of 1H-indazole derivatives to α,β-unsaturated aldehydes is described. The iminium/enamine cascade process lies at the heart of our strategy, leading to enantioenriched fused polycyclic indazole architectures. Variations on both the α,β-unsaturated aldehydes and the indazole-7-carbaldehyde heterocycles were studied in order to broaden the scope of the transformation in synthetically interesting directions. The fused polycyclic indazoles exhibit fluorescence properties and can undergo synthetic transformations.