3196-23-4 Usage
Description
METHYL 1-BROMOCYCLOHEXANECARBOXYLATE is an organic compound that serves as an intermediate in the synthesis of various organic compounds. It is known for its reactivity with zinc and substituted chalcones, amides, or methylamides, leading to the formation of different types of spiro compounds and derivatives.
Uses
Used in Organic Synthesis:
METHYL 1-BROMOCYCLOHEXANECARBOXYLATE is used as a reactant in the synthesis of various organic compounds, including spiro-3,4-dihydropyran-2-one derivatives, 3-aryl-5-aryl-2-oxaspiro[5.5]undec-3-en-1-ones, and 5-aryl-1,3-dioxo-2-azaspiro[5.5]undecane-4-carbonitriles or 5-aryl-2-methyl-1,3-dioxo-2-azaspiro[5.5]undecane-4-carbonitriles.
Used in Improved Preparation Methods:
METHYL 1-BROMOCYCLOHEXANECARBOXYLATE is used as a starting material in the improved method of preparation of methyl 3-oxo-1-cyclohexene-1-carboxylate.
Used in Reformatsky Synthesis:
METHYL 1-BROMOCYCLOHEXANECARBOXYLATE is used in the Reformatsky synthesis of 16-aryl-15-oxadispiro[5.1.5.3]hexadecane-7,14-diones, a reaction involving the reaction of an α-bromoester with an aldehyde or ketone in the presence of a metal, typically zinc, to form a new carbon-carbon bond.
Used in Pharmaceutical Industry:
METHYL 1-BROMOCYCLOHEXANECARBOXYLATE may be used as a building block or intermediate in the synthesis of pharmaceutical compounds, given its reactivity and ability to form various organic compounds.
Used in Chemical Research:
METHYL 1-BROMOCYCLOHEXANECARBOXYLATE is used as a research compound in the study of organic reactions, synthesis, and the development of new methodologies in organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 3196-23-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,1,9 and 6 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 3196-23:
(6*3)+(5*1)+(4*9)+(3*6)+(2*2)+(1*3)=84
84 % 10 = 4
So 3196-23-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H13BrO2/c1-11-7(10)8(9)5-3-2-4-6-8/h2-6H2,1H3
3196-23-4Relevant articles and documents
Reaction of methyl 1-bromocycloalkanecarboxylates with zinc and benzoin
Kirillov,Slepukhin,Nikiforova,Vasyanin,Shurov
, p. 1438 - 1440 (2014)
The Reformatsky reagents derived from methyl 1-bromocyclohexane-or 1-bromocyclopentanecarboxylate and zinc add to benzoin to afford the corresponding 4-hydroxy-3,4-diphenyl-2-oxaspiro[4.5]decan-1-one and 4-hydroxy-3,4-diphenyl-2-oxaspiro[4.4]nonan-1-one.
Iridium(I)-catalyzed vinylic C-H borylation of 1-cycloalkenecarboxylates with bis(pinacolato)diboron
Sasaki, Ikuo,Doi, Hana,Hashimoto, Toshiya,Kikuchi, Takao,Ito, Hajime,Ishiyama, Tatsuo
, p. 7546 - 7548 (2013/08/23)
Ir(i)-catalyzed C-H borylation of 1-cycloalkenecarboxylic derivatives with bis(pinacolato)diboron affords various alkenylboronates with functional groups in excellent yields. This reaction was also used in a one-pot borylation/Suzuki-Miyaura cross-coupling procedure.
Preparation of 2,2-Dihalocarboxylic Acid Methyl Esters by Oxidation-Chlorination of 2-(1-Haloalkyl)-4-methyl-1,3-dioxolanes with Trichloroisocyanuric Acid
Boni, Monica,Ghelfi, Franco,Pagnoni, Ugo Maria,Zucchi, Claudia
, p. 1622 - 1626 (2007/10/02)
Methyl 2,2-dichloro or 2-bromo-2-chloro carboxylates were obtained in excellent yields by oxidation-chlorination of 2-(1-haloalkyl)-4-methyl-1,3-dioxolanes with trichloroisocyanuric acid.
