320580-76-5

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)-
• Synonyms: 1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)-;tert-Butyl (3R)-3-[[(benzyloxy)carbonyl]amino]piperidine-1-carboxylate;(R)-tert-butyl 3-(benzyloxycarbonylamino)piperidine-1-carboxylate;(R)-1-Boc-(3-Cbz-aMino)piperidine;1-Boc-(3R)-3-Cbz-aMinopiperidine;(R)-tert-butyl 3-(((benzyloxy)carbonyl)amino)piperidine-1-carboxylate（WS205065）
• CAS NO: 320580-76-5
• Molecular Formula: C₁₈H₂₆N₂O₄
• Molecular Weight: 334.41
• Mol File: 320580-76-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 471.6 °C at 760 mmHg
• Flash Point: 239 °C
• Appearance: /
• Density: 1.15
• Refractive Index: 1.545
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)-(320580-76-5)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)-(320580-76-5)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 320580-76-5(Hazardous Substances Data)

Usage

General Description

"1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)-" is a complex organic compound that belongs to the class of organic compounds known as N-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid (or a derivative thereof) which bears an acyl group at its terminal nitrogen atom. Specifically, this chemical compound features a piperidine ring, which is a saturated heterocyclic compound containing a six-membered ring with one nitrogen atom. Its molecular structure also carries 1,1-dimethylethyl ester functionalities and a phenylmethoxy carbonyl group, which is a significant functional structure in a myriad of organic reactions. Its specific synthesis, uses, and potential biological activity can be explored further depending on the context in which it is being examined.

InChI:InChI=1/C18H26N2O4/c1-18(2,3)24-17(22)20-11-7-10-15(12-20)19-16(21)23-13-14-8-5-4-6-9-14/h4-6,8-9,15H,7,10-13H2,1-3H3,(H,19,21)/t15-/m1/s1

Upstream product

• 188111-79-7 tert-butyl (3R)3-aminopiperidine-1-carboxylate 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 188111-79-7 tert-butyl (3R)3-aminopiperidine-1-carboxylate 

Relevant articles and documents

Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity

We synthesized derivatives of a natural alkaloid, conolidine, and evaluated these derivatives in the acetic acid-induced writhing test and formalin test in ddY mice after oral administration. As a result, we identified (5S)-6-methyl-1,3,4,5,6,8-hexahydro-7H-2,5-methano[1,5]diazonino[7,8-b]indol-7-one sulfate salt, 15a (DS54360155), with a unique and original bicyclic skeleton, as an analgesic more potent than conolidine. Moreover, 15a did not exhibit mu-opioid receptor agonist activity.

3-substituted piperidines comprising urea functionality, and methods of use thereof

One aspect of the present invention relates to novel heterocyclic compounds comprising urea functionality. A second aspect of the present invention relates to the use of the novel heterocyclic compounds comprising urea functionality as ligands for various cellular receptors, including opioid receptors, other G-protein-coupled receptors and ion channels. An additional aspect of the present invention relates to the use of the novel heterocyclic compounds comprising urea functionality as analgesics.