320727-36-4Relevant articles and documents
Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1
Gopalsamy, Ariamala,Kincaid, Scott L.,Ellingboe, John W.,Groeling, Thomas M.,Antrilli, Thomas M.,Krishnamurthy, Girija,Aulabaugh, Ann,Friedrichs, Gregory S.,Crandall, David L.
, p. 3477 - 3480 (2007/10/03)
A novel series of PAI-1 inhibitors containing an oxadiazolidinedione moiety were identified by high through-put screening. Optimization of substituents by parallel synthesis and the iterative design toward understanding structure-activity relationship to improve potency are described.