321-68-6

Basic information

• Product Name: 2-Amino-4-fluorobiphenyl
• Synonyms: 2-Amino-4-fluorobiphenyl
• CAS NO: 321-68-6
• Molecular Formula: C₁₂H₁₀FN
• Molecular Weight: 187.21
• Mol File: 321-68-6.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Amino-4-fluorobiphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4-fluorobiphenyl(321-68-6)
• EPA Substance Registry System: 2-Amino-4-fluorobiphenyl(321-68-6)

Safety Data

• Hazardous Substances Data: 321-68-6(Hazardous Substances Data)

Usage

General Description

2-Amino-4-fluorobiphenyl, also known as 4-fluoro-2-aminobiphenyl, is a chemical compound with the molecular formula C12H10FN. It is an aromatic amine and a member of the biphenyl class of compounds, containing two benzene rings linked by a single bond. This chemical is used as an intermediate in the production of dyes, pigments, and pharmaceuticals. The fluorine atom in its structure makes it useful in organic synthesis and as a building block for pharmaceutical intermediates. It is also a known mutagen and potential carcinogen, posing health and safety risks to those who handle and work with it. Strict safety measures must be followed when handling 2-Amino-4-fluorobiphenyl to minimize exposure and prevent adverse health effects.

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Relevant articles and documents

Electrochemical Palladium-Catalyzed Intramolecular C—H Amination of 2-Amidobiaryls for Synthesis of Carbazoles

The synthesis of carbazoles based on the electrochemical Pd-catalyzed intramolecular C—H amination of 2-amidobiaryls through oxidative cross coupling has been achieved under mild reaction conditions. The reaction can be carried out in undivided cell without the addition of external chemical oxidant. Besides good functional group compatibility, the desired carbazoles can be scaled up and modified easily. Compared with previous methods, this protocol affords a simple and sustainable avenue for the construction of carbazoles.

Photocatalytic xanthate-based radical addition/cyclization reaction sequence toward 2-biphenyl isocyanides: Synthesis of 6-alkylated phenanthridines

A photocatalytic xanthate-based radical addition/cyclization reaction cascade toward 2-biphenylisocyanides is described as a practical and modular approach to 6-alkylated phenanthridines. The use of xanthates as radical precursors allowed the synthesis of diversely 6-substituted phenanthridines. Electrophilic radicals derived from nitriles, aromatic and aliphatic ketones, malonates, and amide derivatives, as well as radicals derived from phthalimidomethyl and benzylic derivatives were successfully introduced. The reaction proceeds under mild conditions without a stoichiometric amount of oxidant. Thirty novel phenanthridine scaffolds were synthesized with yields ranging from 24 to 76%.

NBE-Controlled Palladium-Catalyzed Interannular Selective C-H Silylation: Access to Divergent Silicon-Containing 1,1′-Biaryl-2-Acetamides

A novel palladium-catalyzed interannular selective C-H silylation of 1,1′-biaryl-2-acetamides is described. The combination of palladium catalyst with copper oxidant enables meta- or ortho-selective C-H silylation by employing hexamethyldisilane as a trimethylsilyl source, which relies on the control of NBE derivatives as a switch, thus providing straightforward access to divergent silicon-containing 1,1′-biaryl-2-acetamides.