321426-45-3Relevant articles and documents
Polythiazole linkers as functional rigid connectors: A new RGD cyclopeptide with enhanced integrin selectivity
Ruiz-Rodriguez,Miguel,Preciado,Acosta,Adan,Bidon-Chanal,Luque,Mitjans,Lavilla,Albericio
, p. 3929 - 3935 (2014)
Polythiazole amino acids clasp linear peptides to generate cyclic derivatives, however, the resulting species are not merely stapled peptides but bear a complex heterocyclic moiety displaying its intrinsic set of interactions. As a proof of concept, a bisthiazole moiety has been grafted onto an RGD sequence to deliver a new cilengitide analogue with improved integrin selectivity and remarkable in vivo antiangiogenic activity.