32202-61-2

Basic information

• Product Name: 4-AMINOINDAN
• Synonyms: 4-AMINOINDAN;4-INDANAMINE;indan-4-amine;4-AMINOINDANE;Einecs 250-950-7;2,3-dihydro-1H-inden-4-amine;Indan-4-amine, 2,3-Dihydro-1H-inden-4-amine;indan-4-ylaMine
• CAS NO: 32202-61-2
• Molecular Formula: C₉H₁₁N
• Molecular Weight: 133.19
• EINECS: 250-950-7
• Product Categories: Indane/Indanone and Derivatives
• Mol File: 32202-61-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 9℃
• Boiling Point: 90-92 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 0.736 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0116mmHg at 25°C
• Refractive Index: n20/D 1.592(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.49±0.20(Predicted)
• CAS DataBase Reference: 4-AMINOINDAN(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINOINDAN(32202-61-2)
• EPA Substance Registry System: 4-AMINOINDAN(32202-61-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 32202-61-2(Hazardous Substances Data)

Usage

Description

4-Aminoindan, also known as 2,3-dihydro-1H-inden-4-amine, is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and chemical compounds. It possesses a unique chemical structure with a 2,3-dihydro-1H-inden-4-yl moiety and an amino group, which allows it to participate in various chemical reactions and form different derivatives.

Uses

Used in Pharmaceutical Synthesis:
4-Aminoindan is used as a key intermediate in the synthesis of pharmaceutical compounds, such as 4,5-dihydro-N-(2,3-dihydro-1H-inden-4-yl)oxazol-2-amine and 1-(2-chloroethyl)-3-(2,3-dihydro-1H-inden-4-yl)urea. These compounds have potential applications in the development of new drugs and therapeutic agents.
Used in Chemical Reactions:
4-Aminoindan is used in nucleophilic addition reactions, such as its reaction with 2-chloroacetylisocyanate to yield 1-(2-chloroacetyl)-3-(2,3-dihydro-1H-inden-4-yl)-urea. This reaction demonstrates the versatility of 4-aminoindan in forming different chemical structures and its potential use in the synthesis of various chemical compounds.

InChI:InChI=1/C9H11N/c10-9-6-2-4-7-3-1-5-8(7)9/h2,4,6H,1,3,5,10H2

Upstream product

• 4044-54-6 2,3-dihydro-1H-indene-4-carboxylic acid 
• 55934-10-6 methyl 1-oxo-2,3-dihydro-1H-indene-4-carboxylate 
• 81329-74-0 3-(2-(methoxycarbonyl)phenyl)propanoic acid 
• 4122-56-9 methyl o-formylbenzoate 
• 1370650-73-9 methyl 2-(3-chloro-3-oxopropyl)benzoate 
• 119-67-5 o-carboxybenzaldehyde 
• 15115-61-4 4-chloro-indan 
• 7647-01-0 hydrogenchloride 
• 34701-14-9 4-nitroindane 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 
• 496-11-7 INDANE 
• 40507-80-0 Indanazolin-monohydrochlorid 

Downstream Products

• 913067-79-5 N-(2,3-dihydro-1H-inden-4-yl)-3-iodo-4-methylbenzamide 
• 713128-72-4 indan-4-yl-dimethyl-amine 
• 1641-41-4 4-indanol 
• 40507-75-3 N-4-Indanyl-N'-benzoyl-thioharnstoff 
• 67356-94-9 N-(1-Acetyl-2-imidazolin-2-yl)-N-(4-indanyl)amin 
• 2660235-13-0 5-methyl-2,3-dihydro-1H-inden-4-amine 
• 2676863-73-1 7-bromo-5-cyclopropyl-2,3-dihydro-1H-inden-4-amine 
• 2260959-47-3 5-bromo-2,3-dihydro-1H-inden-4-amine 

Relevant articles and documents

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NOVEL COMPOUNDS

The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 is a saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include cyclic groups, wherein the hydrocarbyl group may optionally be substituted, and wherein the hydrocarbyl group may optionally include one or more heteroatoms N, O or S in its carbon skeleton; and R2 is a cyclic group substituted at the a-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

New preparation method of 4-aminoindan compound

The invention relates to a new preparation method of a 4-aminoindan compound. 4-Aminoindan is an important medical intermediate. With carboxybenzaldehyde as an initial raw material, through esterification, condensation, cyclization, reduction elimination, Curtius rearrangement, an amidogen deprotection reaction and a hydrogenation reaction in sequence, the 4-aminoindan is prepared. According to the method, the problems of difficult generation of isomers, difficult separation of substitution products and the like in a traditional method are solved, the whole preparation method is convenient toimplement, the yield is high, and the method has great industrial prospects.