32230-08-3

Basic information

• Product Name: 2-[(5-chloropyridin-2-yl)oxy]-2-methylpropanoic acid
• CAS NO: 32230-08-3
• Molecular Formula: C₉H₁₀ClNO₃
• Molecular Weight: 215.6336
• Mol File: 32230-08-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 316.165°C at 760 mmHg
• Flash Point: 145.011°C
• Density: 1.324g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 2-[(5-chloropyridin-2-yl)oxy]-2-methylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(5-chloropyridin-2-yl)oxy]-2-methylpropanoic acid(32230-08-3)
• EPA Substance Registry System: 2-[(5-chloropyridin-2-yl)oxy]-2-methylpropanoic acid(32230-08-3)

Safety Data

• Hazardous Substances Data: 32230-08-3(Hazardous Substances Data)

Usage

Chloropyridine group

5-chloropyridin-2-yl This compound contains a chlorinated pyridine ring, which is a heterocyclic aromatic ring with five members, one of which is nitrogen, and a chlorine atom at the 5th position.

Methylpropanoic acid group

2-methylThe compound also features a methyl group (CH3) attached to a propanoic acid backbone, which is a three-carbon carboxylic acid.

Derivative of propanoic acid

2-[(5-chloropyridin-2-yl)oxy]-2-methylpropanoic acid This compound is derived from propanoic acid by incorporating the chloropyridine and methyl groups, altering its chemical properties and reactivity.

Organic synthesis and pharmaceutical research

The compound is commonly used in the synthesis of various pharmaceutical drugs and other organic compounds due to its unique structure and properties.

Building block for chemical compounds

2-[(5-chloropyridin-2-yl)oxy]-2-methylpropanoic acid serves as a valuable building block for the production of a wide range of chemical compounds, making it an important tool in the field of chemistry.

Upstream product

• 32177-89-2 ethyl 2-methyl-2-(5-chloro-2-pyridyloxy)propionate 
• 4214-79-3 5-chloro-2-pyridinol 

Relevant articles and documents

Discovery of N-{(1S,2S)-2-(3-cyanophenyl)-3-[4-(2-[18F] fluoroethoxy)phenyl]-1-methylpropyl}-2-methyl-2-[(5-methylpyridin-2-yl)oxy] propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use

The discovery of a structurally distinct cannabinoid-1 receptor (CB1R) positron emission tomography tracer is described. Starting from an acyclic amide CB1R inverse agonist (1) as the lead compound, an efficient route to introduce 18F to the mo

Discovery of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1- methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity

The discovery of novel acyclic amide cannabinoid-1 receptor inverse agonists is described. They are potent, selective, orally bioavailable, and active in rodent models of food intake and body weight reduction. A major focus of the optimization process was to increase in vivo efficacy and to reduce the potential for formation of reactive metabolites. These efforts led to the identification of compound 48 for development as a clinical candidate for the treatment of obesity.

RADIOLABELED CANNABINOID-1 RECEPTOR MODULATORS

The present invention relates to particular radiolabeled Cannabinoid-1 (CB1) receptor modulators, and methods of using these modulators for labeling and diagnostic imaging of Cannabinoid-1 receptors in mammals, particularly humans. In addition, intermediates useful for the synthesis of the radiolabeled Cannabinoid-1 receptor modulators are also disclosed, as well as the processes for synthesizing the radiolabeled Cannabinoid-1 receptor modulators. Still further, formulations of the radiolabeled Cannabinoid-1 receptor compounds are described.