322642-40-0

Basic information

• Product Name: 1-(4-methoxybenzyl)-3,3-dimethylpyrrolidine-2,5-dione
• Synonyms: 1-(4-methoxybenzyl)-3,3-dimethylpyrrolidine-2,5-dione
• CAS NO: 322642-40-0
• Molecular Weight: 247.294
• Mol File: 322642-40-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxybenzyl)-3,3-dimethylpyrrolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxybenzyl)-3,3-dimethylpyrrolidine-2,5-dione(322642-40-0)
• EPA Substance Registry System: 1-(4-methoxybenzyl)-3,3-dimethylpyrrolidine-2,5-dione(322642-40-0)

Safety Data

• Hazardous Substances Data: 322642-40-0(Hazardous Substances Data)

Upstream product

• 17347-61-4 2,2-dimethylsuccinic anhydride 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 322642-41-1 4-ethyl-1-(4-methoxy-benzyl)-3,3-dimethyl-pyrrolidine-2,5-dione 

Relevant articles and documents

Synthesis of Chiral γ-Lactams via in Situ Elimination/Iridium-Catalyzed Asymmetric Hydrogenation of Racemic γ-Hydroxy γ-Lactams

Chiral γ-lactams have been synthesized in excellent yields and enantioselectivities (up to 99% yield and 96% ee) from easily accessible racemic γ-hydroxy γ-lactams via an iridium-phosphoramidite catalyzed asymmetric hydrogenation. The reaction was designed based on insight into the reaction mechanism demonstrated in previous work and can be carried out at a reduced catalyst loading of 0.1 mol % on a gram scale. Several potential bioactive compounds can be synthesized from the reduced products. Mechanistic studies indicated that the reduced products were obtained via the hydrogenation of the N-acyliminium cations, generated from γ-hydroxy γ-lactams.