32347-16-3

Basic information

• Product Name: Benzene, [(1R,2S)-2-bromo-2-fluorocyclopropyl]-, rel-
• CAS NO: 32347-16-3
• Molecular Formula: C9H8BrF
• Molecular Weight: 215.065
• Mol File: 32347-16-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzene, [(1R,2S)-2-bromo-2-fluorocyclopropyl]-, rel-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [(1R,2S)-2-bromo-2-fluorocyclopropyl]-, rel-(32347-16-3)
• EPA Substance Registry System: Benzene, [(1R,2S)-2-bromo-2-fluorocyclopropyl]-, rel-(32347-16-3)

Safety Data

• Hazardous Substances Data: 32347-16-3(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 1868-53-7 dibromofluoromethane 

Relevant articles and documents

(NHC)AgCl catalyzed bromofluorocyclopropanation of alkenes with CFBr2CO2Na

An effective method for bromofluorocyclopropanation of electron-rich (aryl substituted), electron-neutral (monoalkyl substituted), electron-poor (haloalkenes, allylic esters, α,β-unsaturated esters) and acid/base sensitive silyl- and boronyl substituted a

Copper-catalyzed ligand free ring-opening amination of gem-fluorohalocyclopropanes – An efficient route toward 2-fluoroallylamines

Ring-opening amination of gem-chlorofluoro- and gem-bromofluorocyclopropanes with secondary alkyl, aryl amines or hydroxylamines catalyzed by copper(I) or copper(II) compounds with no additional ligands affords tertiary 2-fluoroallylamines or hydroxylamines in moderate to excellent yields. The reaction pathway involves isomerization of gem-fluorohalocyclopropanes to 2-fluoroallyl halides followed by in situ nucleophilic substitution of a halide by an N-nucleophile. The p-methoxyphenyl (PMP) protective group is efficient in the preparation of secondary 2-fluoroallylamines by this method. Primary 2-fluoroallylamines can only be obtained by a stepwise protocol including CuX-catalyzed isomerization of gem-fluorohalocyclopropanes to 2-fluoroallylic halides followed by amination.