32353-50-7

Basic information

• Product Name: Pyridinium, 1-ethyl-2-methyl-, bromide
• CAS NO: 32353-50-7
• Molecular Formula: C8H12N.Br
• Molecular Weight: 202.094
• Mol File: 32353-50-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 95 °C
• CAS DataBase Reference: Pyridinium, 1-ethyl-2-methyl-, bromide(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridinium, 1-ethyl-2-methyl-, bromide(32353-50-7)
• EPA Substance Registry System: Pyridinium, 1-ethyl-2-methyl-, bromide(32353-50-7)

Safety Data

• Hazardous Substances Data: 32353-50-7(Hazardous Substances Data)

Usage

Description

Pyridinium, 1-ethyl-2-methyl-, bromide is an organic compound with the chemical formula C7H10BrN. It is a derivative of pyridinium, a heterocyclic compound with a nitrogen atom in the ring structure. The presence of an ethyl group at the 1-position and a methyl group at the 2-position, along with a bromide ion, gives this compound unique chemical properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
Pyridinium, 1-ethyl-2-methyl-, bromide is used as a reagent in the preparation and studies of MKT-077, which are inhibitors of heat shock protein 70 (HSP70) as anticancer agents. HSP70 is a molecular chaperone protein that plays a crucial role in protecting cells from stress and promoting the survival of cancer cells. By inhibiting HSP70, MKT-077 can potentially disrupt the protective mechanisms of cancer cells, leading to their death and reducing tumor growth.

Upstream product

• 109-06-8 α-picoline 
• 74-96-4 ethyl bromide 

Downstream Products

• 1479005-44-1 2-[4-(diethylamino)styryl]-1-ethylpyridinium bromide 

Relevant articles and documents

In Situ Observation of mtDNA Damage during Hepatic Ischemia-Reperfusion

Hepatic ischemia-reperfusion (IR) injury is a severe pathophysiological event during liver surgery or transplantation and could lead to liver failure or even death. The energy supply of mitochondria plays an essential role in preventing IR injury. Mitochondrial DNA (mtDNA) is involved in maintaining the balance of energy by participating in an oxidative phosphorylation process. However, the exact relationship between IR and mtDNA remains unclear by reason of the lack of an accurate real-time analysis method. Herein, we fabricated a mitochondria-targeting fluorescent probe (mtDNA-BP) to explore mtDNA stability and supervise the changes in mtDNA in IR liver. By virtue of pyridinium electropositivity and suitable size, mtDNA-BP could accumulate in mitochondria and insert into the mtDNA groove, which made mtDNA-BP fluoresce strongly. This is attributed to the reduction of the intramolecular rotation energy loss that is restricted by DNA. By in situ fluorescence imaging, we observed in real time that mtDNA damage was aggravated by deteriorating IR injury, so the ROS-mtDNA-mediated IR damage signal pathway was speculated. Furthermore, on the basis of mtDNA-BP real-time response capability for mtDNA, we established a drug-screening method for inhibiting IR injury and found superior therapeutic performance of two potential drugs: pioglitazone and salidroside. This work contributes to our understanding of mtDNA-related disease and provides a new drug analysis method.

PROCESSES FOR PREPARING N-ETHYL-2-METHYLPYRIDINIUM BROMIDE AND N-ETHYL-3-METHYLPYRIDINIUM BROMIDE

The invention provides processes for preparing concentrated aqueous solutions of N-ethyl-2-methylpyridinium bromide and N- ethyl-3-methylpyridinium bromide, which solutions are useful as additives in the electrolyte of hydrogen/bromine electrochemical cells. Also provided are concentrated aqueous solutions of N-ethyl-2-methylpyridinium bromide, N-ethyl-3-methylpyridinium bromide and their mixtures.

Heterocyclic β-dioxoenamines. II. Pyrid-4-yl-1,3-indandiones and their C- and N-substituted derivatives

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