32399-13-6

Basic information

• Product Name: 2-(Methylamino)pyridine-3-carboxylic acid
• Synonyms: 2-(methylamino)-3-Pyridinecarboxylic acid ;2-(Methylamino)nicotinic acid;2-(Methylamino)pyridine-3-carboxylic acid;Albb-004269;2-(methylamino)nicotinic acid(SALTDATA: FREE)
• CAS NO: 32399-13-6
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15
• Mol File: 32399-13-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 250-255°C
• Boiling Point: 336.5 °C at 760 mmHg
• Flash Point: 157.3 °C
• Appearance: /
• Density: 1.327g/cm³
• Vapor Pressure: 4.38E-05mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.86±0.36(Predicted)
• CAS DataBase Reference: 2-(Methylamino)pyridine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Methylamino)pyridine-3-carboxylic acid(32399-13-6)
• EPA Substance Registry System: 2-(Methylamino)pyridine-3-carboxylic acid(32399-13-6)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 32399-13-6(Hazardous Substances Data)

Usage

General Description

2-(Methylamino)pyridine-3-carboxylic acid is a chemical compound that consists of a pyridine ring with a carboxylic acid group at the 3-position and a methylamino group at the 2-position. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-(Methylamino)pyridine-3-carboxylic acid has a wide range of applications in medicinal chemistry and drug development due to its potential as a building block for the synthesis of bioactive molecules. Its unique structure and properties make it a valuable tool for chemical research and drug discovery, and it is often utilized in the production of various pharmaceuticals and organic compounds.

InChI:InChI=1/C7H8N2O2/c1-8-6-5(7(10)11)3-2-4-9-6/h2-4H,1H3,(H,8,9)(H,10,11)

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 74-89-5 methylamine 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 103976-61-0 ethyl 2-(methylamino)pyridine-3-carboxylate 
• 32399-12-5 2-(N-methylamino)-3-hydroxymethylpyridine 
• 103976-52-9 2-(methylamino)pyridine-3-carboxamide 
• 128271-33-0 Methyl-(3-phenylsulfanylmethyl-pyridin-2-yl)-amine 
• 127555-45-7 1-Methyl-3-phenylsulfanyl-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one 
• 1092768-72-3 C₂₃H₂₈ClN₃O₃ 
• 1239164-10-3 1-(ethylthiomethyl)-3-(2-hydroxy-6-oxo-1-cyclohexenecarbonyl)-1,8-naphthyridin-2(1H)-one 
• 1239164-58-9 3-oxo-1-cyclohexenyl 1-(ethylthiomethyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate 
• 1402844-05-6 benzylidene-2-(methylamino)nicotinic acid hydrazide 

Relevant articles and documents

HYDROPYRAZINO[1,2-D][1,4]DIAZEPINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE

The present invention relates to compounds of formula (I), wherein R1 to R3 and n are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

HEXAHYDRO-1H-PYRAZINO[1,2-A]PYRAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE

The present invention relates to compounds of formula (I), wherein R1 to R3, n and A are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

Design and synthesis of niflumic acid-based N-acylhydrazone derivatives as novel anti-inflammatory and analgesic agents

A new series of niflumic acid-based N-acylhydrazone derivatives 5a-p were synthesized and evaluated for their anti-inflammatory and analgesic activities. Most of the compounds have shown anti-inflammatory activity with a moderate-to-excellent activity range (20-80 % reduction in inflammation). Among them, 3-chlorophenyl 5d and 3-pyridyl derivatives 5o exhibited the most potent anti-inflammatory activity relative to niflumic acid as the reference drug (77, 76, and 70 % reduction in inflammation at 1-h postdrug administration, respectively). Also, molecular simplification of niflumic acid through replacing the N-aryl group with N-methyl group produced compounds 6a-f with anti-inflammatory activity in a quite similar manner to those of their parent derivatives. In this subgroup, 4-pyridyl derivative 6f showed the most potent anti-inflammatory activity relative to niflumic acid (80 % reduction in inflammation at 1-h postdrug administration). The compounds with highest anti-inflammatory activity were subjected to analgesic assays and showed moderate-to-excellent analgesic activities. The compound 5j, 4-methoxy derivative, exhibited the highest analgesic activity relative to niflumic acid (97 and 68 % activity, respectively).