32446-66-5

Basic information

• Product Name: N-(2-AMINO-BENZOTHIAZOL-6-YL)-ACETAMIDE
• Synonyms: AKOS BB-8277;4,4'-DICYANOBENZOPHENONE;ASISCHEM Z25293;IFLAB-BB F0909-0068;N-(2-AMINO-1,3-BENZOTHIAZOL-6-YL)ACETAMIDE;N-(2-AMINOBENZO[D]THIAZOL-6-YL) ACETAMIDE;N-(2-AMINO-BENZOTHIAZOL-6-YL)-ACETAMIDE;4,4'-Carbonylbis-benzonitrile
• CAS NO: 32446-66-5
• Molecular Formula: C₁₅H₈N₂O
• Molecular Weight: 232.24
• EINECS: 1533716-785-6
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 32446-66-5.mol
• Article Data: 21

Chemical Properties

• Melting Point: 162 °C
• Boiling Point: 457.782 °C at 760 mmHg
• Flash Point: 230.658 °C
• Appearance: /
• Density: 1.267 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• CAS DataBase Reference: N-(2-AMINO-BENZOTHIAZOL-6-YL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-AMINO-BENZOTHIAZOL-6-YL)-ACETAMIDE(32446-66-5)
• EPA Substance Registry System: N-(2-AMINO-BENZOTHIAZOL-6-YL)-ACETAMIDE(32446-66-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 32446-66-5(Hazardous Substances Data)

Usage

Chemical Properties

Light Brown Solid

Uses

Letrozole intermediate.

Upstream product

• 74032-49-8 S-(2-pyridinyl) 4-cyanobenzenecarbothioate 
• 54008-11-6 C₃₅H₂₄N₄ 
• 3988-03-2 bis(4-bromophenyl)methanone 
• 544-92-3 copper(I) cyanide 
• 611-98-3 4,4'-diaminobenzophenone 
• 151-50-8 potassium cyanide 
• 3058-39-7 4-iodobenzonitrile 
• 623-00-7 4-bromobenzenecarbonitrile 
• 108-24-7 acetic anhydride 
• 220213-92-3 (4-cyanophenyl)zinc(II) iodide 
• 201230-82-2 carbon monoxide 
• 126747-14-6 4-cyanophenylboronic acid 
• 611-97-2 bis(p-methylphenyl)-methanone 
• 98-86-2 acetophenone 

Downstream Products

• 134521-16-7 4,4'-Methanol-bisbenzonitrile 
• 127222-97-3 C₂₄H₁₆N₂O₂ 
• 964-68-1 4,4'-benzophenonedicarboxylic acid 
• 145531-11-9 bis(4-tert-butoxycarbonylphenyl)methanone 
• 174471-86-4 Bis(4-tert-butoxycarbonylphenyl) ketone hydrazone 
• 174471-75-1 Bis(4-tert-butoxycarbonylphenyl)diazomethane 
• 102661-66-5 4,4'-styrylidene-di-benzonitrile 
• 959427-94-2 4-[2,2-bis(4-cyanophenyl)ethenyl]bromobenzene 
• 1131906-45-0 1,1-bis(4-cyanophenyl)-2-methoxyethene 
• 64568-34-9 4-[(4-cyanophenyl)methanehydrazonoyl]benzonitrile 

Relevant articles and documents

Base-free oxidation of alcohols enabled by nickel(ii)-catalyzed transfer dehydrogenation

An efficient nickel(ii)-catalyzed transfer dehydrogenation oxidation of alcohols is reported that relies on cyclohexanone as the formal oxidant and does not require the use of an external base. The synthetic utility of this protocol is demonstratedviathe facile oxidation of structurally complicated natural products.

Method for preparing symmetric diarylketone through catalytic oxidative carbonylation

The invention discloses a method for preparing symmetric diarylketone of a formula (I) as shown in the description. The method comprises the following steps: mixing arylboronic acid (II) (Ar-B(OH)2 (II)), a palladium catalyst, a promoter and an organic solvent in a reactor, introducing air and CO having a volume ratio of (7-19):1, reacting under the conditions of a pressure of 1-6 atm and a temperature of 30-80 DEG C for 8-16 hours, and performing after-treatment on the reaction solution, thereby obtaining the product symmetric diarylketone. According to the method disclosed by the invention,the air directly serves as an oxidizing agent to replace the O2 to be applied to oxidative carbonylation of the arylboronic acid, and the ratio of the air to CO is beyond an explosion limit. Therefore, the catalytic system is safe and economic. The palladium catalyst is small in dosage and simple in separation and can be recycled for several times. The method disclosed by the invention is mild inreaction condition, excellent in substrate suitability and high in yield.

Palladium-Catalyzed Carbonylative Homocoupling of Aryl Iodides for the Synthesis of Symmetrical Diaryl Ketones with Formic Acid

A convenient method for the palladium-catalyzed carbonylative homocoupling of aryl iodides was developed. With formic acid as the CO source, various symmetrical diaryl ketones were synthesized in moderate to good yield in the presence of a palladium catalyst.