326914-10-7 Usage
Description
5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE, also known as SU11652, is a cell-permeable pyrrole-indolinone compound with potent tyrosine kinase receptor and angiogenic inhibitory properties. It is characterized by its unique molecular structure, which includes a chlorinated indole moiety and a diethylaminoethyl substituent, contributing to its biological activity.
Uses
Used in Pharmaceutical Industry:
SU11652 is utilized as a tyrosine kinase receptor inhibitor for its ability to target and inhibit the activity of specific tyrosine kinase receptors involved in cell signaling and growth. This makes it a valuable compound in the development of drugs for the treatment of various diseases, including cancer.
Used in Anti-angiogenic Therapy:
As an angiogenic inhibitor, SU11652 is employed in anti-angiogenic therapy to prevent the formation of new blood vessels that supply nutrients to tumors, thereby inhibiting their growth and spread. This application is particularly relevant in cancer treatment, where it can help control tumor progression and metastasis.
Used in Research Applications:
SU11652 is also used as a research tool in the study of tyrosine kinase receptor signaling pathways and angiogenesis. Its ability to inhibit these processes makes it a valuable compound for investigating the molecular mechanisms underlying various diseases and for identifying potential therapeutic targets.
Check Digit Verification of cas no
The CAS Registry Mumber 326914-10-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,6,9,1 and 4 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 326914-10:
(8*3)+(7*2)+(6*6)+(5*9)+(4*1)+(3*4)+(2*1)+(1*0)=137
137 % 10 = 7
So 326914-10-7 is a valid CAS Registry Number.
326914-10-7Relevant articles and documents
Discovery of 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2, 4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase
Sun, Li,Liang, Chris,Shirazian, Sheri,Zhou, Yong,Miller, Todd,Cui, Jean,Fukuda, Juri Y.,Chu, Ji-Yu,Nematalla, Asaad,Wang, Xueyan,Chen, Hui,Sistla, Anand,Luu, Tony C.,Tang, Flora,Wei, James,Tang, Cho
, p. 1116 - 1119 (2007/10/03)
To improve the antitumor properties and optimize the pharmaceutical properties including solubility and protein binding of indolin-2-ones, a number of different basic and weakly basic analogues were designed and synthesized. 5-[5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2, 4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide (12b or SU11248) has been found to show the best overall profile in terms of potency for the VEGF-R2 and PDGF-Rβ tyrosine kinase at biochemical and cellular levels, solubility, protein binding, and bioavailability. 12b is currently in phase I clinical trials for the treatment of cancers.
Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
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, (2008/06/13)
The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
