32709-74-3Relevant articles and documents
1-Alkyl-3-amino-5-aryl-1H-[1,2,4]triazoles: Novel synthesis via cyclization of N-Acyl-S-methylisothioureas with alkylhydrazines and their potent corticotropin-Releasing factor-1 (CRF1) receptor antagonist activities
Chen, Chen,Dagnino Jr., Raymond,Huang, Charles Q.,McCarthy, James R.,Grigoriadis, Dimitri E.
, p. 3165 - 3168 (2001)
Cyclizations of alkylhydrazines with N-acyl-S-methylisothioureas, readily synthesized from acyl chlorides, sodium thioisocyanate, dialkylamines then methyl iodide in a one-pot reaction, gave 1-alkyl-3-dialkylamino-5-phenyltriazoles 7 as major products. The regioisomers were assigned through the use of NOE NMR experiments. While bearing a N-bis(cyclopropyl)methyl-N-propylamino group, this series of compounds shows very good binding affinity on the human CRF1 receptor. Among them, 1-methyl-3-[N-bis(cyclopropyl)methyl-N-propylamino]-5-(2,4-dichlorophenyl)- 1H-[1,2,4]triazole 7a had the best binding affinity for the CRF1 receptor (Ki=9 nM).
Synthesis and characterization of N,N-Di-substituted acylthiourea copper(II) complexes
Wu, Su-Yun,Zhao, Xiao-Ya,Li, Hai-Pu,Yang, Ying,Roesky, Herbert W.
, p. 883 - 889 (2015/04/27)
A series of six N,N-di-substituted acylthiourea ArC(O)NHC(S)NRR ligands (denoted as HLn) [Ar = 1-Naph: NRR = NPh2, HL1 (1); N(iPr)Ph, HL2 (2). Ar = Mes: NRR = NPh2, HL4 (3); N(iPr)Ph, HLsu
