327602-34-6

Basic information

• Product Name: 2-AMino-5,6-dichloro-3,4-dihydroquinazoline HydrobroMide
• Synonyms: 2-AMino-5,6-dichloro-3,4-dihydroquinazoline HydrobroMide;5,6-Dichloro-1,4-dihydro-2-quinazolinaMine HydrobroMide
• CAS NO: 327602-34-6
• Molecular Formula: C8H8BrCl2N3
• Molecular Weight: 297
• Product Categories: Amines;Bases & Related Reagents;Impurities;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Nucleotides;Pharmaceuticals;Amines, Impurities, Isotope Labelled Compounds, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 327602-34-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-AMino-5,6-dichloro-3,4-dihydroquinazoline HydrobroMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-5,6-dichloro-3,4-dihydroquinazoline HydrobroMide(327602-34-6)
• EPA Substance Registry System: 2-AMino-5,6-dichloro-3,4-dihydroquinazoline HydrobroMide(327602-34-6)

Safety Data

• Hazardous Substances Data: 327602-34-6(Hazardous Substances Data)

Usage

Uses

Anagrelide (A637300) metabolite, the major metabolite in hematopoietic cell cultures.

Upstream product

• 6334-18-5 2,3-dichlorobenzylaldehyde 
• 506-68-3 bromocyane 
• 147249-42-1 6-amino-2,3-dichlorobenzylamine 

Downstream Products

• 875467-37-1 C₁₄H₁₅Cl₂N₃O₃ 

Relevant articles and documents

Synthesis and stability of 3-hydroxyanagrelide, a biologically potent metabolite of anagrelide

Metabolism of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin- 2-one (anagrelide), a drug for treating essential thrombocythemia, gives 6,7-dichloro-3-hydroxy-1,5-dihydroimidazo[2,1-b]quinazolin-2-one (3-hydroxyanagrelide) and 2-amino-5,6-dichloro-3,4-dihydroquinazoline. To enable the properties of 3-hydroxyanagrelide to be fully evaluated, the racemic compound has been synthesized. In pH 7.4 aqueous buffer 3-hydroxyanagrelide readily equilibrates with an isomer, 6,7-dichloro-1-hydroxy-3,5- dihydroimidazo[1,2-a]- quinazolin-2-one, and is also hydrolyzed to 2-amino-5,6-dichloro-3,4-dihydroquinazoline. 3-Hydroxyanagrelide (half-life 40 hours) was the dominant species at equilibrium and it was concluded that the equilibration and decomposition are sufficiently slow that published assays of 3-hydroxyanagrelide are reliable.